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NCT Number: NCT07741201

Healing After Injury to Reduce Opioid Use and Pain Through Preventive Engagement

The goal of this proposed project is to optimize the adaptive psychological intervention and assess the feasibility and acceptability. The long-term objective of this line of research is to evaluate whether an adaptive psychological intervention delivered after a musculoskeletal injury is effective in preventing the development of chronic pain and long-term opioid use.

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Key information

Conditions

Pain Neurologic Manifestations Opioid Use Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Admitted to Henry Ford Hospital
  • Has an acute musculoskeletal injury
  • Prescribed opioids during the admission

Exclusion criteria

  • Under age 18
  • Cognitive impairment (i.e., diagnosis of delirium, dementia, or traumatic brain injury/Glasgow Coma Scale less than 13)
  • Chronic pain condition (i.e., pain most of the day, nearly every day for the past 3 months or longer)
  • Taking opioids within the 30 days prior to this hospitalization

Treatment and study plan

Computerized brief intervention

Behavioral

Education about long-term opioid use and a mindfulness strategy

Psychological sessions

Behavioral

Four sessions composed of education, mindfulness, and acceptance-based strategies.

Opioid taper recommendations

Behavioral

Recommendations will be provided to taper opioid use.

Primary outcomes

  1. Opioid use

    Time frame: 90-day follow-up

    Whether patient was using opioids

Secondary outcomes

  1. Morphine Dose Equivalent (MDE)

    Time frame: 90-day follow-up

    Dose of opioid use in MDEs

  2. Presence of chronic pain

    Time frame: 90-day follow-up

    Whether a patient reports experiencing pain from the injury

  3. Pain severity

    Time frame: 90-day follow-up

    On a 0-10 scale, patients rate their current pain and average, least, and worst pain over the previous week.

  4. Pain interference

    Time frame: 90-day follow-up

    Participants report on a 0-10 scale how much the pain interferes across a variety of daily activities.

  5. Mindfulness

    Time frame: 90-day follow-up

    The MAAS is a validated, 15 item measure that questions how often a patient engages in mindfulness experiences on a 1 (almost always) to 6(almost never) point scale; scores are summed to produce a total score.

  6. Pain acceptance

    Time frame: 90-day follow-up

    The CPAQ is 20 items with two validated subscales: Activities Engagement and Pain Willingness. A total score is achieved by summing these two subscales. Items are on a 0 (Never True) to 6 (Always True) Likert Scale.

  7. Depression

    Time frame: 90-day follow-up

    The PHQ-9 is a 9-item measure that assesses severity of depressive symptoms.

  8. Anxiety

    Time frame: 90-day follow-up

    The GAD-7 assesses severity of anxiety symptoms. Scores greater or equal to 10 indicate a high likelihood of current anxiety.

  9. Sleep

    Time frame: 90-day follow-up

    The Insomnia Severity Index (ISI) measures sleep difficulty. The ISI has 7-items on a 0 to 4.

  10. Impact of Events Scale Revised

    Time frame: 90-day follow-up

    This 22-item measure asks participants to respond to their level of distress regarding a specified event on a 0 to 4 scale over the past 7 days.

  11. Opioid misuse

    Time frame: 90-day follow-up

    The COMM is a 17-item measure that asks participants about behaviors associated with opioid misuse. Scores of 9 or greater are considered positive for opioid misuse.

Study contacts

Contact information is provided by the study sponsor or research team.

Lisa Matero, PhD

CONTACT

[email protected]

313-874-5454

Sponsors and collaborators

Lead sponsor

Henry Ford Health System

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

An Adaptive Psychological Intervention to Improve Pain and Reduce Opioid Use Following an Injury

Acronym: HOPE

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Aug 3, 2026
Registry last updated
Aug 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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