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NCT Number: NCT07197658

Healing After Endodontic Microsurgery Using a Rotary Bur Versus Piezoelectric Unit for Osteotomy and Root Resection

The goal of this clinical trial is to compare bone healing after using apical tooth microsurgery to remove root end infection, either by use of rotary burs for cutting bone and root end, or by use of piezoelectric surgery for the same procedures.

The main questions it aims to answer are:

* Is there a difference in bone healing and reformation between the two surgical procedures ? * Is there a difference in bone healing between cutting the bone with a rotary bur and cutting the bone with the 'bone window' technique that uses piezoelectric unit ?

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Private Dental Office, Athens, Attica, Greece

Loading trial locations.

About this study

The aim of this study is to prospectively compare postsurgical healing after the use of microsurgical technique to eliminate apical pathology, either by use of rotary burs for osteotomy and root resection, or by use of piezoelectric surgery for the same clinical procedures. Null hypothesis is that there is no difference in healing and buccal bone thickness reformation between the two surgical procedures Another purpose of the study is to prospectively evaluate healing after the application of a novel buccal bone preservation technique, called the 'bone window' technique. The technique will be applied in a subgroup of patients on maxillary and mandibular premolar and molar teeth with an intact buccal cortical bone and healing and buccal bone reformation will be assessed at follow up. Null hypothesis in this part, is that there is no difference in healing and buccal bone preservation between osteotomy with a bur and the 'bone window' technique.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 years and older consenting to the surgical procedure as well as agreeing to preoperative, postoperative and at least one follow-up CBCT evaluation after 12 months
  • Noncontributory medical history (American Society of Anesthesiologists class I and II)
  • A history of previous endodontic treatment with radiographic presence of apical periodontitis
  • A true endodontic lesion: microsurgical classification A, B, or C according to Kim and Kratchman, 2006.
  • Lesion size 10 mm or smaller in diameter measured on preoperative CBCT
  • Coronal restoration should be present at the time of follow up examination.

Exclusion criteria

  • Nonconsenting patients and patients younger than 18 years of age
  • Medical history with American Society of Anesthesiologists class III to V
  • Insufficient coronal restoration
  • Nonrestorability or traumatized teeth
  • Teeth with microsurgical classification D, E, or F according to Kim and Kratchman, 2006.
  • Mobility I or higher
  • Radiographic presence of nonapical root resorption
  • Teeth with a vertical root fracture or coronal/ midroot perforation
  • Lesion size larger than 10 mm in diameter measured on preoperative CBCT
  • Use of bone graft material for regeneration

Treatment and study plan

endodontic microsurgery / rotary bur osteotomy

Procedure

Endodontic microsurgery will be executed by use of a rotary bur

Other names: bur osteotomy, endodontic microsurgery

Endodontic microsurgery / piezo osteotomy

Procedure

Endodontic microsurgery will be performed by use of a piezosurgery unit

Other names: endodontic surgery, surgical endodontic retreatment, piezosurgery

Endodontic microsurgery / bone window

Procedure

'Bone window' technique will be performed by use of piezoelectric surgery

Other names: apical surgery, bone lid

Primary outcomes

  1. Two dimensional radiographic bone healing

    Time frame: From execution of the microsurgical procedure to one year or later follow up examination

    Bone healing will be measured on periapical radiograph using well established two dimensional criteria for bone healing assessment. Molven's criteria categorize healing using periapical films into four categories: complete healing, incomplete healing, uncertain and unsatisfactory healing

  2. Three dimensional radiographic bone healing

    Time frame: From execution of the microsurgical procedure to one year or later follow up examination

    Bone healing will be measured on Cone Beam Computed Tomography (CBCT) scan using well established three dimensional criteria for bone healing assessment. Penn 3D criteria categorize healing using CBCT scans into three categories: complete healing, limited and unsatisfactory healing

Sponsors and collaborators

Lead sponsor

National and Kapodistrian University of Athens

Other

Registry information

Official study title

Prospective Healing Assessment After Application of Endodontic Microsurgery for Elimination of Apical Pathology By Use of Either a Rotary Bur for Osteotomy and Apical Root Resection, or Piezoelectric Unit for the Same Clinical Procedures

Acronym: BURVSPIEZO

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Sep 29, 2025
Registry last updated
Jun 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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