Head Stabilization of Healthy Volunteers

A robotic platform will use data from motion-detection cameras to position a person's head in real time. This procedure is non-invasive and since healthy volunteers are enrolled in this study, no radiation is delivered, but in the future, the investigators plan to use this device during radiation treatment with patients.

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Key information

Conditions

Healthy

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

About this study

This study aims to passively monitor the real-time head motions of healthy volunteers positioned to simulate whole brain radiation therapy. Such real-time head motion data is necessary in order to understand the type (amplitude/frequency) of motion that the robotic stage will be expected to compensate for and will play an important role in the overall modeling and designing process of the robotic prototype.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Subjects 18 and older
Subjects must be able to read and understand English
Participants must sign the informed consent form

Exclusion criteria

Any subjects not meeting the above inclusion criteria will not be considered for this study.

Treatment and study plan

Real-time head stabilization with robotic platform

Device

A robotic platform will use data from motion-detection cameras to position a person's head in real time. This procedure is non-invasive.

Primary outcomes

Collection of Head Motion Data to be Used in Developing Head Stabilization Methods in Brain Radiation Patients

Time frame: One-time session, up to 4 hours on a single day.

Real-time intracranial target motion was continuously monitored using a commercial surface-guided radiation therapy (SGRT) system operating at approximately 10 frames per second. For each participant, translational (mm) and rotational (degree) motion of the target were computed relative to the starting head position at setup. The target position was tracked in six degrees of freedom (longitudinal, lateral, vertical translation; pitch, roll, yaw rotation). To provide a quantitative endpoint reflecting system effectiveness, the recorded 6D target motion data were analyzed and positional deviation histograms showing the total percentage of time that the target remained below a specific translational and rotational tolerance level were generated. The percentage of time that the target remained below a tolerance of < 1.0 mm translational and < 1.0° rotational deviation was chosen as the single primary outcome measure.

Sponsors and collaborators

Lead sponsor

Abramson Cancer Center at Penn Medicine

Other

Collaborators

National Cancer Institute (NCI)

Registry information

Official study title

Real-Time Head Position Stabilization of Healthy Volunteers

Important dates

Study start: 2022
Primary completion: 2024
Study completion: 2025
First posted: Aug 12, 2025
Registry last updated: Feb 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed