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NCT Number: NCT05959551

HD-tDCS to Modulate Connectivity

The purpose of the proposed study is to broaden our understanding on the neural effects of High Definition Transcranial Direct Current Stimulation (HD-tDCS) so that its clinical effects can be further improved.

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Key information

Conditions

Electricity; Effects

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Manitoba

Winnipeg, Manitoba, R3E 0J9, Canada

Location status: Recruiting

Location contact

Ji Hyun Ko, PhD

CONTACT

[email protected]

204-318-2566

About this study

Normal healthy individuals will be recruited and undergo a standardized neuropsychological assessment (ANAM, MoCA, BDI-II, ToMS, and MAAS) and magnetic resonance imaging (MRI). During MRI, HD-tDCS will be applied. Four different stimulation targets will be investigated, and subjects will be randomly assigned for each target groups or sham group. After HD-tDCS/MRI session, subjects will be re-assessed with standardized neuropsychological tests.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All other than excluded.

Exclusion criteria

  • History or susceptibility to any neurological or psychiatric diseases, particularly seizures
  • abnormal MRI
  • metal implants or a cardiac pacemaker
  • pregnant or breastfeeding women

Treatment and study plan

High Definition transcranial direct current stimulation (HD-tDCS)

Device

HD-tDCS will be provided for 20 minutes for each stimulation with peak intensity of 2mA.

Primary outcomes

  1. change of functional connectivity

    Time frame: 0-11 minutes after the stimulation contrasting baseline (before stimulation)

    Changes in seed-based connectivity originating from the targeted brain regions immediately after the brain stimulation

Secondary outcomes

  1. change of cerebral blood flow

    Time frame: 12-16 minutes after the stimulation contrasting baseline (before stimulation)

    Changes in Cerebral Blood Flow (estimated using pseudo continuous arterial spin labeling )

  2. Toronto Mindfulness Scale (curiosity)

    Time frame: Baseline, then within 1-2 hours from stimulation

    mindfulness scale for curiosity. min: 0, max: 30. Higher score means higher curiosity-mindfulness.

  3. Toronto Mindfulness Scale (decentering)

    Time frame: Baseline, then within 1-2 hours from stimulation

    mindfulness scale for decentering. min: 0, max: 35. Higher score means higher decentering-mindfulness.

Study contacts

Contact information is provided by the study sponsor or research team.

Ji Hyun Ko, PhD

CONTACT

[email protected]

2042930724

Sponsors and collaborators

Lead sponsor

University of Manitoba

Other

Collaborators

  • Natural Sciences and Engineering Research Council, Canada

Registry information

Official study title

Modulating Functional Brain Connectivity Using High Definition Transcranial Direct Current Stimulation (HD-tDCS)

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Jul 25, 2023
Registry last updated
May 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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