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Completed

NCT Number: NCT05969834

HCG Levels After Ovulation Triggering as Predictors of ICSI Outcome

This study aimed to assess the correlation between HCG levels after ovulation triggering and ICSI outcomes, affected by HCG formulation and dose

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

18 year–35 year

Sex eligibility

Female

Study type

Observational

Primary location

Royal Center

Al Mansurah, Dakahlia Governorate, 35516, Egypt

About this study

The aims of this study are:

  • To assess the correlation between serum human chorionic gonadotropin (hCG) level after ovulation triggering and intracytoplasmic sperm injection (ICSI) outcome including: oocyte maturity and quality, good quality embryo rate, blastocyst formation rate and pregnancy rate
  • To determine if there is an association between type and dose of the trigger and ICSI outcome.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women who will undergo controlled ovarian stimulation (COS) through fixed GnRH antagonist protocol

Exclusion criteria

  • BMI > 30 kg/m2
  • Irregular menstruation
  • Severe male factor abnormality
  • Poor ovarian reserve
  • Endometriosis
  • Uterine abnormality

Treatment and study plan

uHCG

Drug

Final oocyte maturation will be triggered by IM administration of 10000 IU of uHCG (Choriomon)

Other names: Choriomon

rHCG

Drug

Final oocyte maturation will be triggered by SC administration of 6500 IU of rHCG (Ovitrelle)

Other names: Ovitrelle

uHCG and GnRHa

Drug

Final oocyte maturation will be triggered by combined SC administration of 0.1 mg of GnRHa (Decapeptyl, Triptorelin) and IM administration of 2500 IU of uHCG (Choriomon)

Other names: Decapeptyl and Choriomon

Primary outcomes

  1. Clinical pregnancy rate

    Time frame: 6 weeks after embryo transfer

    Number of clinical pregnancies (defined as presence of at least one intrauterine gestational sac with fetal pole and cardiac activity on TVS scan at 4-6 weeks after the ET) divided by the number of ET procedures

Secondary outcomes

  1. Oocyte maturation rate

    Time frame: On 1 day of oocyte retrieval

    Number of mature oocytes divided by the number of retrieved oocytes

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

Human Chorionic Gonadotropin Levels After Ovulation Triggering as Predictors of Intracytoplasmic Sperm Injection Outcome

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Aug 1, 2023
Registry last updated
Aug 1, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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