hCAP18 Levels and Vitamin D Deficiency in Healthy Subjects

Vitamin D deficiency (low levels of vitamin D in the blood) is a common problem. A recently discovered protein, called hCAP18, likely plays an important role in the immune system and may depend on adequate levels of vitamin D. It is not known what levels of vitamin D are needed to allow the body to make this protein. Nor is it known if giving vitamin D to people who are found to be deficient will help boost levels of hCAP18. This study aims to clarify the relationship between vitamin D levels and hCAP18.

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Key information

Conditions

Healthy Subjects Avitaminosis Deficiency Diseases Malnutrition Nutrition Disorders Nutritional and Metabolic Diseases Vitamin D Deficiency

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 18-80

Exclusion criteria

Known active infectious disease or chronic inflammatory disorder
Hypercalcemia
Chronic kidney disease
Pregnancy

Treatment and study plan

Ergocalciferol

Drug

Ergocalciferol 50,000 IU given every other day for 5 total doses

Other names: Vitamin D

Primary outcomes

hCAP18 Levels

Time frame: Baseline
Baseline 25-OH Vitamin D Level

Time frame: Baseline

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Registry information

Important dates

Study start: 2007
Primary completion: 2012
Study completion: 2012
First posted: Aug 27, 2008
Registry last updated: Apr 14, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed