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Completed

NCT Number: NCT02655172

Have a Good Grasp of the Worldthe World

Brief Summary: In schizophrenia, dislocation of psychic functions involving a loss of contact with reality is frequently found. A fragmentation of motor and sensory perceptions could be held responsible. However, automatic integration between perception and action is the necessary condition to be in "relationship with the world." Affordance is the experimental link between object perception and potentially associated actions (Gibson, 1977, 1979) explored by Stimulus Response Compatibility (SRC) paradigm. With Tucker & Ellis sensory motor compatibility task (1998), with a modified response device (responses given with grasp), we study the impact of motor activation on these affordance effects. In this study, a group of controls will also be included in order to understand, as precisely as possible, the mechanisms involved (i.e., interference between the perception of the object and the response gesture).

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Key information

Conditions

Schizophrenic Disorders Mental Disorders Schizophrenia Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chu Saint-Etienne

Saint-Etienne, 42055, France

About this study

Schizophrenic patients will perform: Alert TEA, (Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield, 1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale, Kay et al., 1987). Controls will only perform the laterality questionnaire. Then all will perform the affordance task, in which photographs of 20 objects of everyday life, typically graspable with one hand, are presented in 4 orientations. Participants have to respond in a graspable device, as quickly as possible, if the object is presented upright or inverted.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • For patients:
  • a DSM-IV diagnosis of schizophrenia (men or women),
  • no change in antipsychotic medication and clinical status within four weeks prior to the study
  • For patients and control group • Age ≥ 18 years et ≤ 55 years

Exclusion criteria

  • History of head trauma,
  • neurological disease with cerebral repercussion or not stabilized serious physical illness;
  • psychotropic medication
  • disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

Exclusion criteria

  • For patients:
  • IQ < 70
  • For patients and control group
  • History of head trauma,
  • neurological disease with cerebral repercussion or not stabilized serious physical illness;
  • psychotropic medication
  • disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

Treatment and study plan

cognitive tasks + PANSS+ IQ

Other

Patients will perform different tasks: reaction time (Alert TEA, Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield,1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale (Kay et al., 1987) + the experimental task (affordance task with graspable device)

cognitive tasks

Other

Healthy volunteers will perform only Edinburgh laterality questionnaire (Oldfield, 1971) + the experimental task (affordance task with graspable device).

Primary outcomes

  1. response time

    Time frame: day 1

    The gain provided by the compatible vs incompatible conditions (ms response time)

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Saint Etienne

Other

Registry information

Official study title

Study on the Links Between Action and Perception in Schizophrenia, " Have a Good Grasp of the World "

Acronym: GRASP

Important dates

Study start
2016
Primary completion
2019
Study completion
2019
First posted
Jan 13, 2016
Registry last updated
Sep 6, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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