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OpenTrials
Completed

NCT Number: NCT06592937

Harmonized and Pooled Database, Named PRIME.

We merged the dataset of three large observational studies of invasive ventilation in critically ill patients.

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Key information

Conditions

Invasive Ventilation

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Amsterdam, Netherlands

About this study

PRIME contains the individual patient data of 3 large observational studies of ventilation, 'PRactice of VENTilation in critically ill patients without ARDS' (PRoVENT), 'PRactice of VENTilation in critically ill patients in Middle-income Countries' (PRoVENT-iMiC) and 'Extubation strategies and in neuro-intensive care unit patients and associations with outcomes' (ENIO).

Who can participate

Only the study team can determine whether someone qualifies for participation.

All patients in the PRIME database are eligible for participation in the initial analysis presented here. We will exclude patients receiving ventilation fir another reason than acute brain injury.

Treatment and study plan

Invasive ventilation

Other

Invasive ventilation and respiratory support

Primary outcomes

  1. ICU morality

    Time frame: ICU stay, anticipated average 15 days

    any mortality occurred during ICU stay

Secondary outcomes

  1. Mechanical Power

    Time frame: During the first 7 days of invasive ventilation

    All variables or parameters recorded from the ventilator, when the patient is under mechanical ventilation, to calculate the mechanical power (calculated in Joule/minute)

Sponsors and collaborators

Lead sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Other

Registry information

Official study title

Potentially Modifiable Ventilation Factors Associated With Outcome in Neurocritical Care vs Non-Neurocritical Care Patients - Rational and Protocol for a Patient-Level Analysis of PRoVENT, PRoVENT-iMiC and ENIO (PRIME)

Acronym: PRIME

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Sep 19, 2024
Registry last updated
Sep 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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