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OpenTrials
Completed

NCT Number: NCT01793675

Haplo-identical/Mismatched Hematopoietic Stem Cell Transplantation for Myelodysplastic Syndrome

Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only curative treatment for myelodysplastic syndrome (MDS), especially for advanced MDS (blast >5%). However, many patients cannot find an HLA-matched donor. haploidentical donor is an alternative stem cell source.

the study hypothesis: Haploidentical/mismatched hematopoietic stem cell transplantation can improve the survival of patients with myelodysplastic syndrome

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Key information

Conditions

Advanced MDS Without Identical Sibling Donor

Age range

2 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Nanfang Hospital, Nanfang Medical University, Guangzhou, Guangdong, China

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with MDS (1)intermediate-2 or high risk (2)low or intermediate-1 risk with drug resistance or disease progression
  • without identical sibling donor

Exclusion criteria

  • Contraindication to HSCT
  • Pregnancy
  • Mental illness

Treatment and study plan

transplant with haploidentical donor

Procedure

patients with advanced MDS without identical sibling donor receive haploidentical transplant

Other names: haploidentical transplant

Primary outcomes

  1. survival rate

    Time frame: participants will be followed for an expected average of one year

    number of participants with survival at one year

Secondary outcomes

  1. incidence of non-relapse mortality

    Time frame: one year

    number of participants with non-relapse mortality at one year

Sponsors and collaborators

Lead sponsor

Peking University People's Hospital

Other

Registry information

Important dates

Study start
2003
Primary completion
2012
Study completion
2014
First posted
Feb 15, 2013
Registry last updated
Apr 29, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.