running
DeviceRunning 10 kilometers on a treadmill
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NCT Number: NCT06670742
Gut-muscle Axis: Exploring the Gut Microbiota Influences Host Energy Sources and Exercise Performance
Through training, the investigators can adjust the composition and functions of gut microbiota. Exercise also alters the body's energy metabolism pathways, which, in turn, impacts the gut microbiota and its metabolic products. Understanding how the body utilizes and regulates energy during exercise is essential for enhancing athletic performance. This study aims to explore the relationships among post-exercise energy metabolites, gut microbiota, and their metabolic products, applying omics technologies in the field of sports science.
This interdisciplinary research will contribute to fields such as exercise physiology, sports nutrition, exercise biochemistry, and sports medicine, providing innovative and practical research insights for advancing sports science in our country.
Not Yet Recruiting
Trial opening soon.
Get NotifiedKey information
Conditions
Age range
20 year–65 year
Sex eligibility
Male
Study type
Interventional
Phase
Not applicable
About this study
The gut microbiota, which is comprised of trillions of microbes, is the collective term for the gut microbiota. It establishes a symbiotic relationship with the host and plays a vital role in maintaining host health. Through training, the investigators can adjust the composition and functions of gut microbiota. Exercise also alters the body's energy metabolism pathways, which, in turn, impacts the gut microbiota and its metabolic products. Understanding how the body utilizes and regulates energy during exercise is essential for enhancing athletic performance. This study aims to explore the relationships among post-exercise energy metabolites, gut microbiota, and their metabolic products, applying omics technologies in the field of sports science.
This interdisciplinary research will contribute to fields such as exercise physiology, sports nutrition, exercise biochemistry, and sports medicine, providing innovative and practical research insights for advancing sports science in our country.
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Marathon Running Group
Inclusion criteria
- Training frequency of at least 3 times per week in the past year, with each session involving at least 1 hour of running.
- Participation in at least 2 marathon events within the past 2 years, with a completion time of under 4 hours and 30 minutes for a full marathon, or under 2 hours and 15 minutes for a half marathon.
Exclusion criteria
- Excludes individuals with cardiovascular diseases, hypertension, epilepsy, bronchitis, severe asthma, heart disease, inflammatory bowel disease, bacterial or viral infections, disabilities, or chronic bone diseases.
- Habitual smokers.
- Individuals with highly irregular eating habits or sleep patterns due to shift work or night work.
- History of chronic neuro-muscular injuries or disorders in the past 6 months.
- Individuals who have received antibiotic treatment or taken probiotic supplements in the past 6 months.
General Healthy Adult Group
Inclusion criteria
- Generally healthy, untrained individuals.
Exclusion criteria
- Excludes individuals with cardiovascular diseases, hypertension, epilepsy, bronchitis, severe asthma, heart disease, inflammatory bowel disease, bacterial or viral infections, disabilities, or chronic bone diseases.
- Habitual smokers.
- Individuals with highly irregular eating habits or sleep patterns due to shift work or night work.
- History of chronic neuro-muscular injuries or disorders in the past 6 months.
- Individuals who have received antibiotic treatment or taken probiotic supplements in the past 6 months.
Treatment and study plan
Primary outcomes
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Concentration of lactate
Time frame: The testing time points are set as follows: before exercise, at the 5-kilometer mark during exercise, immediately after exercise, and at 5, 15, 30, and 60 minutes post-exercise.
Measure changes in lactate concentration.
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Concentration of creatine kinase
Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.
Measure changes in creatine kinase concentration.
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Concentration of glucose
Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.
Measure changes in glucose concentration.
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Concentration of creatinine
Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.
Measure changes in creatinine concentration.
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Concentration of blood urea nitrogen
Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.
Measure changes in blood urea nitrogen concentration.
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Concentration of lactate dehydrogenase
Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.
Measure changes in lactate dehydrogenase concentration.
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Concentration of free fatty acid
Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.
Measure changes in free fatty acid concentration.
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Concentration of cortisol
Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.
Measure changes in cortisol concentration.
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ood frequency questionnaire(FFQ)
Time frame: Before exercise
The participants' diets were assessed using a semiquantitative food frequency questionnaire(FFQ). The FFQ used in this study was validated in a previous study; the questionnaire exhibited reliability and validity for identifying major nutrients in the diets of Taiwanese vegetarians and omnivores.(Chiu TH et al., 2014) In this study, the nutrient analysis programme used to calculate the results of the FFQ was based on Taiwan's Food Composition Database. To assess the intake frequency of each food item, frequencies ranged from "never" or "<1 time per month" to "more than 2 times per day.
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Gut microbiota analysis
Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and at 24 and 48 hours post-exercise.
Collect participant stool samples for gut microbiota analysis.
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Untargeted metabolome analysis
Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and at 24 and 48 hours post-exercise.
Collect participant stool samples for metabolome analysis.Metabolite identification aims to analyze the metabolome composition of biological samples, investigate the regulation of metabolic pathways, and explore biochemical mechanisms.
Secondary outcomes
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Body composition
Time frame: Before exercise
The investigators used the InBody 570 (In-body, Seoul, South Korea), the bioelectrical impedance analyzer (BIA) to measure body composition. The device can screen frequencies of 1, 5, 50, 260, 500 and 1000 kHz within 60 seconds. After cleaning the palms and soles of the feet, the subject stood vertically on the electrodes of the instrument, holding the sensing handle with both hands and keeping the arms away from the body at a 30° angle, and avoided talking or moving during the measurement. The device measured body weight (kg), BMI (kg/m²), fat mass (%), and lean mass (kg).
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Rate of Perceived Exertion(RPE)
Time frame: The testing time points are set as follows: before exercise, at the 5-kilometer mark during exercise, and immediately after exercise.
Assess perceived exercise intensity.
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Heart rate
Time frame: The testing time points are set as follows: before exercise, at the 5-kilometer mark during exercise, and immediately after exercise.
Assess changes in heart rate.
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
National Taiwan Sport University
Other
Registry information
Official study title
Gut-muscle Axis: Exploring the Gut Microbiota Influences Host Energy Sources and Exercise Performance Via Modulation of Lactate Metabolism and Utilization
Important dates
- Study start
- 2024
- Primary completion
- 2024
- Study completion
- 2024
- First posted
- Nov 1, 2024
- Registry last updated
- Nov 1, 2024
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.