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OpenTrials
Completed

NCT Number: NCT06748339

Gut Microbiome and Colorectal Cancer

Colorectal cancer (CRC) is reported to be the third leading cause of cancer deaths worldwide, and its prevalence is steadily rising in developing countries. It can be considered a marker of socioeconomic development and a marker of significant changes in food habits and lifestyle. In Egypt, CRC represents the seventh most common cancer. It is the third most reported cancer in males and the fifth most common cancer in females. microbiome dysbiosis may be involved in the pathogensis and thus pose a therapeutic target

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Key information

Conditions

Colorectal Cancer Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Rectal Diseases

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

cairo university Hopitals (elKasr ELieny )

Cairo, Egypt

About this study

Many reports suggested the role of westernized dietary lifestyles, including high consumption of red meats, animal fats, and cholesterol-rich foods, as well as smoking, decreased physical activity, obesity, diabetes, alcohol consumption, or smoking, in CRC development. These changes in lifestyle are called the external factors, which are now linked to changes in the inner gut microenvironments, mainly the microbiomes. Our aim is to investigate the the changes in microbiome profile in relation to clinical, pathological and lifestyle factors

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age of 40 years to 80 years
  • Patients with a newly diagnosed CRC

Exclusion criteria

  • Patients with previously known CRC
  • Pregnancy or Lactation
  • Abdominal surgery within/up to 6 months prior to sample collection
  • Antibiotics, corticosteroids, or probiotics up to three months prior to sample collection
  • History of other types of cancer
  • Subjects on a special diet
  • Diabetes, liver, or kidney diseases
  • CRC patients who used enema or underwent colonoscopy up to one week before sample collection.

Treatment and study plan

No intervention

Other

no intervention

Primary outcomes

  1. The effect of food and lifestyle on microbiome

    Time frame: "through study completion, an average of 1 year"

    correlation between food and lifestyle with microbiome profiles

  2. microbiome profile and CRC pathogensis

    Time frame: "through study completion, an average of 1 year"

    correlation between microbiome profile and CRC pathogensis

Sponsors and collaborators

Lead sponsor

Heliopolis University

Other

Registry information

Official study title

Gut Microbiome Dyspiosis in Colorectal Cancer Egyptian Patients

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Dec 27, 2024
Registry last updated
Dec 27, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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