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Completed

NCT Number: NCT00869453

Gut Hormone Secretion and Macronutrients

The role of gut hormone (GLP-1, GIP, PYY...) in glucose homeostasis has been widely demonstrated. Furthermore modifications in their pattern of secretion seem to be involved in the improvement of glucose control in obese patients after bariatric surgery.

The purpose of this study is to assess the respective role of carbohydrate, fat and protein from a complete meal in gut hormones secretion.

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Key information

Conditions

Healthy Volunteers

Age range

18 year–35 year

Sex eligibility

Male

Study type

Observational

Primary location

Cardiomet Clinical research Center, CHUV, Lausanne, Canton of Vaud, Switzerland

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About this study

The study is designed to asses the role of each individual macronutrient of a compete meal in gut hormones secretion in healthy volunteers.

8 healthy young male subjects will be studied on 5 different occasions. To asses the role of each macronutient the subjects will recieve one of the following test meal: a complete sandwich, the proteic part of this complete meal, the glucidic part and the lipidic part. The fifth test will be a fasting test.

To assess the entero-insular axis, a 5.5 hours hyperglycaemic clamp will be performed.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male
  • 18-35 years old
  • 19 kg/m2 ≤ BMI ≤ 25 kg/m2
  • Healthy
  • Low to moderate physical activity
  • Non smokers

Exclusion criteria

  • Family history of diabetes mellitus
  • Any medication
  • Participation to blood spending or other clinical study in the 3 months before the beginning of this study
  • Consumption of drugs
  • Consumption of more than 50g of alcool in a week
  • Vegetarian or particular diet
  • Anamnèse d'intolérance alimentaire
  • Family history of food intolerance

Treatment and study plan

Test meal

Other

Mixed meal containing bread, butter, beef

Glucose

Other

administration of a glucose meal

fat

Other

administration of a lipid meal

Protein

Other

administration of a protein meal

Control

Other

no meal

Primary outcomes

  1. Gut hormone secretion

    Time frame: within 4 hours following a test meal

Secondary outcomes

  1. Entero-insular axis measurement

    Time frame: within 4 hours following a test meal

  2. Glucose turnover

    Time frame: 6 hours

  3. Insulin sensitivity

    Time frame: 6 hours

  4. Substrate oxidation

    Time frame: 6 hours

Sponsors and collaborators

Lead sponsor

University of Lausanne

Other

Collaborators

  • Centre Hospitalier Universitaire Vaudois

Registry information

Official study title

Gut Hormone Secretion Pattern in Response to Different Macronutrients in Healthy Volunteers

Important dates

Study start
2009
Primary completion
2009
Study completion
2009
First posted
Mar 26, 2009
Registry last updated
Jul 3, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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