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NCT Number: NCT04932525

Gustave Roussy Cancer Profiling

The objective of STING study is to perform high throughput molecular analysis (next generation sequencing +/- immunological profiling) to estimate the proportion of patients with cancer presenting at least one targetable genomic alteration.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gustave Roussy Cancer Campus Grand Paris, Villejuif, Val de Marne, France

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About this study

STING is a biology driven, multicenter study designed to identify actionable molecular alterations in cancer patients and to explore mechanisms of sensitivity and resistance to anti-cancer treatment

  • In this trial, high throughput analysis will be carried out using next generation sequencing, and immunological profiling
  • Patients included in the STING study and for whom a targetable genomic alteration had been identified might be subsequently included in a clinical trial running at Gustave Roussy or another participating center.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years
  • Histology: solid malignant tumor or hematological malignancy.
  • Patient with a social security in compliance with the French law relating to biomedical research (Article L.1121-11 of French Public Health Code)
  • Voluntary signed and dated written informed consent prior to any study specific procedure.

Exclusion criteria

  • Any condition which in the Investigator's opinion makes it undesirable for the subject to participate in a clinical trial or which would jeopardize compliance with the protocol
  • Patient under guardianship or deprived of his liberty by a judicial or administrative decision or incapable of giving its consent
  • Pregnant or breast-feeding women
  • Minors (Age < 18 years)

Treatment and study plan

Biopsy

Procedure

Blood and tumor samples for Genetic Profiling research

Primary outcomes

  1. Number of patients presenting at least one targetable genomic alteration

    Time frame: 2 months after the last enrollment

    Number of patients presenting at least one targetable genomic alteration

  2. Proportion of patients presenting at least one targetable genomic alteration

    Time frame: 2 months after the last enrollment

    Proportion of patients presenting at least one targetable genomic alteration

Secondary outcomes

  1. Rate of molecular profiling information including utilization of information for standard regimens or clinical trials of molecularly targeted therapies

    Time frame: 2 months after the last enrollment

    For a patient with molecular results available utilization of molecular profiling information is defined as Inclusion in a clinical trial assessing a drug matched to the molecular alteration And/or Treatment with an approved drug matched with the molecular alteration

  2. Objective response rate

    Time frame: 24 months post treatment after the last enrollment

  3. Progression-free survival

    Time frame: 24 months post treatment after the last enrollment

  4. Overall survival

    Time frame: 24 months post treatment after the last enrollment

Study contacts

Contact information is provided by the study sponsor or research team.

Antoine Italiano, MD PhD

CONTACT

[email protected]

+33 (0)1 42 11 42 11 ext. 34 71

Clementine MAHAUT

CONTACT

[email protected]

+33 (0)1 42 11 23 34

Sponsors and collaborators

Lead sponsor

Gustave Roussy, Cancer Campus, Grand Paris

Other

Registry information

Acronym: STING

Important dates

Study start
2021
Primary completion
2033
Study completion
2033
First posted
Jun 21, 2021
Registry last updated
Feb 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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