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NCT Number: NCT07548398

Gummy Smile and Altered Passive Eruption Prevalence

This observational epidemiological study aims to assess the prevalence of gummy smile and altered passive eruption in a young adult population, with a focus on the second sextant. Periodontal and aesthetic parameters, along with patient-reported discomfort, will be analyzed to identify potential correlations and underlying anatomical factors.

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Key information

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sapienza università di Roma

Roma, RM, 00161, Italy

Location status: Recruiting

Location contact

Fabrizio Guerra

CONTACT

[email protected]

3283150627

About this study

The primary aim of this study is to evaluate the prevalence of gummy smile, with particular focus on altered passive eruption, in a young adult population. Additionally, the study seeks to analyze key aesthetic and periodontal parameters in order to better understand their role in the etiology and clinical manifestation of excessive gingival display. Special attention is given to the second sextant, which is most frequently involved in gummy smile, to investigate the local distribution of these alterations and their diagnostic relevance.

Furthermore, the study aims to explore the relationship between the extent of gingival exposure and variations in periodontal parameters, while also assessing the level of aesthetic, psychological, and social discomfort perceived by affected individuals. Data analysis will also allow the identification of potential individual anatomical factors, such as the position of the mucogingival junction and clinical crown dimensions, that may be associated with altered passive eruption.

This is an observational epidemiological study designed to evaluate periodontal aesthetic parameters in patients attending their first clinical visit. The study will also assess the presence of aesthetic discomfort, investigate possible correlations, and explore the need for treatment related to second sextant conditions. Patients selected according to specific inclusion and exclusion criteria will undergo an operator-patient interview to collect anamnestic and clinical data. documentation.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male and female subjects;
  • Age between 18 and 50 years;
  • Periodontally healthy subjects;
  • Patients with no history of orthodontic treatment;
  • Patients without gingival hypertrophy or hyperplasia.

Exclusion criteria

  • Age < 18 or > 50 years;
  • Patients diagnosed with Stage I-IV periodontitis;
  • Patients currently undergoing orthodontic treatment;
  • Patients with severe dental crowding in the second sextant;
  • Patients taking medications associated with gingival hypertrophy or -hyperplasia;
  • Patients unwilling to provide informed consent;
  • Patients with fixed or removable prostheses in the second sextant;
  • Patients with a history of surgical procedures in the second sextant;
  • Patients with uncontrolled diabetes or neuropsychiatric disorders;
  • Patients with infectious diseases;
  • Pregnant or breastfeeding women, or those with suspected pregnancy;
  • Patients taking bisphosphonates;
  • Oncologic patients and those undergoing head and neck radiotherapy or receiving chemotherapy;
  • Patients with alcohol or drug abuse.

Treatment and study plan

Clinical Assessment

Other

Non-invasive clinical evaluation including measurement of aesthetic indices (PES/WES), and intraoral photographic documentation.

Primary outcomes

  1. Gingival display during smiling

    Time frame: Baseline (single visit)

    Quantitative assessment of gingival display during posed smile, measured as the vertical distance (in millimeters) between the inferior border of the upper lip and the gingival margin of the maxillary central incisors. Continuous variable (mm), measured using a calibrated periodontal probe and standardized intraoral photographs.

  2. Prevalence of altered passive eruption (APE)

    Time frame: Baseline

    Assessment of the presence of altered passive eruption based on clinical crown dimensions and gingival margin position relative to anatomical landmarks. Measurement scale: Categorical variable (Presence/Absence)

Secondary outcomes

  1. Clinical crown length of maxillary anterior teeth

    Time frame: Baseline

    Measurement of the clinical crown length (in millimeters) of maxillary anterior teeth, from the incisal edge to the gingival margin with a periodontal probe.

Study contacts

Contact information is provided by the study sponsor or research team.

Fabrizio Guerra

CONTACT

[email protected]

3283150627

Sponsors and collaborators

Lead sponsor

University of Roma La Sapienza

Other

Registry information

Official study title

Prevalence of Gummy Smile and Altered Passive Eruption in a Young Adult Population.

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Apr 23, 2026
Registry last updated
Apr 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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