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NCT Number: NCT07394933

Guided Bone Regeneration Using Ti-Reinforced PTFE Membrane Vs. Khoury's Technique in Augmentation of Posterior Mandibular Defects

The aim of the present clinical trial is to compare two different alveolar ridge bone augmentation techniques for mandibular horizontal bone defects.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Atrophic Ridge

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry - The British University in Egypt

Cairo, Egypt

About this study

Will using PTFE membrane with a mixture of xenograft and particulate autogenous bone result in bone gain similar to standard Khoury's bone shell technique?

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Have one or more missing teeth in the posterior mandibular segment.
  • The alveolar ridge in the edentulous site of the selected patients will have a buccolingual width of less than 5 mm.
  • Sufficient vertical bone height above inferior alveolar nerve.
  • Free of any local or systemic condition that may contraindicate ridge expansion procedure.
  • No sex predilection.
  • The patient will be between the ages of 18-70 years.

Exclusion criteria

  • Patients taking any medication that may interfere with bone healing or bone biology.
  • Patients with any systemic disease that may affect bone healing.
  • Any patients with any previous bone grafting procedure at the site of interest.
  • Heavy Smokers (more than 20 cigarettes daily).
  • Patient's that have been diagnosed with periodontal disease, as sufficient ridge height would be improbable.

Treatment and study plan

Khoury's bone shell technique

Procedure

Bone blocks will be harvested from the retromolar area after measuring of the size required and measuring of the donor site anatomy. Piezoelectric device will be used to perform the graft osteotomy. The block size should be slightly larger than the defect size. Sharp bony edges will be smoothened, and the donor defect will be packed with gelatin sponges. The bone block margins will be smoothened and separated into two thinner bone shells using titanium disk with copious saline irrigation. The blocks will be fixed into the recipient site buccally using at least two micro-screws leaving a gap to be filled with bone graft.

GBR using Ti-reinforced PTFE Membrane

Procedure

A non-resorbable ti-enforced polytetrafluoroethylene (PTFE) membrane will be fixed with titanium screws on the lingual bone plate and on the buccal bone plate allowing for packing of particulate mix of bone graft (50% Xenograft: 50% Autogenous graft).

Primary outcomes

  1. Cone Beam Volumetric Topography (CBVT)

    Time frame: 6 Months

Secondary outcomes

  1. Clinical measurement: the frequency of complications

    Time frame: 6 Months

Sponsors and collaborators

Lead sponsor

British University In Egypt

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Feb 6, 2026
Registry last updated
Feb 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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