Growth Hormone Resistance of Beta-cells

Inclusion criteria

• body mass index >18.5kg/m2 and <45.9kg/m2
• impaired fasting glucose >/= 100mg/dL, </= 126mg/dL or impaired glucose tolerance on 75g oral glucose tolerance test (blood glucose 140 to 199mg/dL at two-hours)

Exclusion criteria

• pregnant, planning to become pregnant during the study, or breastfeeding
• current diagnosis or history of type 1 or type 2 diabetes
• use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists)
• history of bariatric surgery
• known, uncontrolled hypothyroidism
• history of intracranial hypertension, including papilledema, or a condition that increases the risk of developing intracranial hypertension, such as Turner Syndrome, Prader-Willi Syndrome, or renal impairment
• current cancer or cancer that has been in remission less than 5 years
• first degree relative with type 1 diabetes
• evidence of anemia or significant end organ dysfunction (e.g., liver, kidney, heart disease)
• alcohol use disorder, use of controlled substances, or smoking >2 cigarettes per day
• greater than 3% weight loss within three months of screening or engaged in regular (>/= 3 days per week), continuous moderate- or high-intensity exercise of >/= 30 min duration
• mentally disabled persons, prisoners, and persons with inability to grant voluntary informed consent