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NCT Number: NCT07681310

GreenArt: Nutrikinetics and Bioavailability Studies

The aim of this study is to investigate phenolic compounds from GreenArt, a baccharis-type propolis ingredient, bioavailability and nutrikinetics by measuring urinary excretion and metabolic profile over 48h by means of high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). The study follows a cross-over, double-blind, randomized and placebo control design on 10 healthy subjects.

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Key information

Conditions

Nutrition, Healthy

Age range

25 year–69 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Provision of signed and dated informed consent form.
  • Stated willingness to comply with all study procedures and availability for the duration of the study.
  • Male and female with 40% min. and 60% max. of each sex.
  • Aged 25 to 69 years old
  • BMI range (18.5 - 29.99)
  • In good general health as evidenced by medical history
  • Ability to take oral supplementation and be willing to adhere to the regimen
  • Agreement to adhere to Lifestyle Considerations (controlled diet) throughout study duration

Exclusion criteria

  • Current use of any medication or food supplement
  • Antibiotic use less than 12 weeks before the study
  • Pregnancy or lactation
  • Known allergic reactions to components of the supplement, i.e., bee products (specially propolis) and known allergy (general)
  • Metabolic disorders or any kind of disease
  • Current smoker

Treatment and study plan

GreenArt D is a baccharis-type propolis powder extract containing phenolic compounds such as prenylated phenylpropanoids derived from hydroxycinnamic acids and flavonoids.

Dietary Supplement

GreenArt D contains 150 mg of GreenArt

GreenArt 4D is a baccharis-type propolis powder extract containing phenolic compounds such as prenylated phenylpropanoids derived from hydroxycinnamic acids and flavonoids.

Dietary Supplement

GreenArt 4D contains 600 mg of GreenArt

Placebo

Dietary Supplement

Placebo is composed of the carriers of GreenArt : gum arabic, sucrose and silicon dioxide mix.

Primary outcomes

  1. Change in plasma area under the curve (AUC) of phenolic metabolites after acute ingestion of the supplement/placebo

    Time frame: Baseline (pre-ingestion) to 24 hour post-ingestion

    Plasma samples will be collected in EDTA tubes in baseline before supplement/placebo intake (0h) and up to 24h according to the time frame. Phenolic compounds metabolites in plasma will be identified and quantified by HPLC-MS. Targeted metabolites are prenylated phenolic acids, phenolic acids and flavonoids derivatives. For each identified and quantified metabolite the area under the curve (0-24 hour) in nmol/L-h is measured.

  2. Change in plasma maximal concentration (Cmax) of phenolic metabolites after acute ingestion of the supplement/placebo

    Time frame: Baseline (pre-ingestion) and 0.5 hour, 1 hour, 2 hour, 3 hour, 4 hour, 6 hour, 8 hour, 10 hour, 24 hour post-ingestion

    Plasma samples will be collected in EDTA tubes in baseline before supplement/placebo intake (0h) and up to 24h according to the time frame. Phenolic compounds metabolites in plasma will be identified and quantified by HPLC-MS. Targeted metabolites are prenylated phenolic acids, phenolic acids and flavonoids derivatives. For each identified and quantified metabolite the maximal concentration in nmol/L is measured.

  3. Change in plasma time to reach maximal concentration (Tmax) of phenolic metabolites after acute ingestion of the supplement/placebo

    Time frame: Baseline (pre-ingestion) and 0.5 hour, 1 hour, 2 hour, 3 hour, 4 hour, 6 hour, 8 hour, 10 hour, 24 hour post-ingestion

    Plasma samples will be collected in EDTA tubes in baseline before supplement/placebo intake (0h) and up to 24h according to the time frame. Phenolic compounds metabolites in plasma will be identified and quantified by HPLC-MS. Targeted metabolites are prenylated phenolic acids, phenolic acids, and flavonoids derivatives. For each identified and quantified metabolite the time to reach maximum concentration in hour is measured.

  4. Change in urine area under the curve (AUC) phenolic metabolites excretion after acute ingestion of the supplement/placebo

    Time frame: Baseline (pre-ingestion) to 48 hour post-ingestion

    Urine samples will be collected in baseline (0h pre-ingestion) and up to 48h according to the time frame. Phenolic compounds metabolites in urine will be identified and quantified by HPLC-MS. Targeted metabolites are prenylated phenolic acids, phenolic acids and flavonoids derivatives. For each identified and quantified metabolite the area under the curve (0-24 hour) in nmol/L-h is measured.

  5. Change in urine maximal concentration (Cmax) phenolic metabolites excretion after acute ingestion of the supplement/placebo

    Time frame: Baseline (pre-ingestion) and 0 hour - 3 hour, 3 hour - 6 hour, 6 hour - 10 hour, 10 hour - 14 hour, 14 hour - 24 hour, 24 hour - 36 hour and 36 hour - 48 hour post-ingestion

    Urine samples will be collected in baseline (0h pre-ingestion) and up to 48h according to the time frame. Phenolic compounds metabolites in urine will be identified and quantified by HPLC-MS. Targeted metabolites are penylated phenolic acids, phenolic acids and flavonoids derivatives. For each identified and quantified metabolite the maximal concentration in nmol/L is measured.

  6. Change in urine time to reach maximal concentration (Tmax) phenolic metabolites excretion after acute ingestion of the supplement/placebo

    Time frame: Baseline (pre-ingestion) and 0 hour - 3 hour, 3 hour - 6 hour, 6 hour - 10 hour, 10 hour - 14 hour, 14 hour - 24 hour, 24 hour - 36 hour and 36 hour - 48 hour post-ingestion

    Urine samples will be collected in baseline (0h pre-ingestion) and up to 48h according to the time frame. Phenolic compounds metabolites in urine will be identified and quantified by HPLC-MS. Targeted metabolites are prenylated phenolic acids, phenolic acids and flavonoids derivatives. For each identified and quantified metabolite the time to reach maximum concentration in hour is measured.

Study contacts

Contact information is provided by the study sponsor or research team.

Julien Cases, PhD

CONTACT

[email protected]

+33467219098

Sponsors and collaborators

Lead sponsor

Fytexia

Industry

Registry information

Official study title

Baccharis-type Propolis Extract, GreenArt: Nutrikinetics and Bioavailability Studies

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 2, 2026
Registry last updated
Jul 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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