Greater Houston Area Pediatric Bipolar Registry

Inclusion criteria

for bipolar patients or offspring of bipolar parents:

• Any current mood state (in the case of bipolar subjects)
• For bipolar patients: DSM-V criteria for BD type I, BD type II, or BD NOS, as per the administration of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
• For the offspring of bipolar parents: at least one parent meeting DSM-V criteria for BD type I or BD type II, or BD NOS as per the administration of the MINI Adult

Exclusion criteria

for bipolar patients or offspring of bipolar parents:

• Autism Spectrum Disorder (ASD)
• Developmental Intellectual Disorder
• Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
• Schizophrenia
• Uncontrolled or severe medical problem per investigator judgment
• For the offspring: parents with a history of any brain diseases, including seizures, stroke, meningitis, encephalitis, dementia, and other degenerative brain diseases; parents with a history of intellectual disability

Exclusion criteria

for healthy control subjects:

• Any Psychiatric Diagnosis
• Any family history of Bipolar Disorder, Psychotic Disorder, Schizophrenia, or Schizoaffective disorder in a first-degree relative
• Any family history of a neurological condition in a first-degree relative.
• Mental Retardation/Intellectual Disability
• Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
• Schizophrenia
• Uncontrolled or severe medical problem per investigator judgement

Exclusion criteria

for annual visits:

• Autism Spectrum Disorders (ASD)
• Intellectual Developmental Disorder
• Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
• Schizophrenia
• Uncontrolled or severe medical problem per investigator judgement