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Completed

NCT Number: NCT02544230

Granulocyte Transfusions in Hematological Patients With Febrile Neutropenia

The investigators retrospectively evaluated the efficacy of granulocyte transfusions as adjunctive treatment for severe infections in neutropenic fever unresponsive to antimicrobial therapy in hematological patients.

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Key information

Conditions

Neutropenia Agranulocytosis Bacterial Infection Bacterial Infections Bacterial Infections and Mycoses Body Temperature Changes Cytopenia Fever Fever of Unknown Origin Fungal Infection Hematologic Diseases Hematologic Neoplasms Hematological Neoplasms Hemic and Lymphatic Diseases Infections Inflammation Leukocyte Disorders Leukopenia Mycoses Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Signs and Symptoms Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Catholic University of Sacred Heart

Rome, 00168, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • fever;
  • presence of absolute neutrophil count <0.5 x 10^9/L
  • evidence of bacterial or fungal infections (including clinical signs of infection, positive cultures or biopsy, and radiological evidences)
  • unresponsiveness to appropriate antimicrobial therapy for at least 48 hours

Exclusion criteria

  • none

Treatment and study plan

Primary outcomes

  1. Infection-related mortality

    Time frame: within 30 days after the last granulocyte transfusion

    deaths due to infection occurred within 30 days after the last granulocyte transfusion

Sponsors and collaborators

Lead sponsor

Sorveglianza Epidemiologica Infezioni Fungine Emopatie Maligne

Other

Registry information

Official study title

Efficacy of Granulocyte Transfusions for the Treatment of Severe Infections in Hematological Patients With Febrile Neutropenia

Important dates

Study start
2004
Primary completion
2011
Study completion
2011
First posted
Sep 9, 2015
Registry last updated
Sep 9, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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