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OpenTrials
Completed

NCT Number: NCT02784457

Gonadotropin Releasing Hormone Antagonist in Treatment of Early-onset Severe Ovarian Hyperstimulation Syndrome

Efficacy of the use of GnRH antagonist in treatment of those who develop early-onset severe ovarian hyperstimulation syndrome and had cancelled embryo transfer

Completed

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Key information

Conditions

Assisted Reproduction

Age range

20 year–42 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 2

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women who develop early-onset severe ovarian hyperstimulation syndrome after controlled ovarian stimulation using long GnRH agonist protocol and hCG for triggering ovulation.

Exclusion criteria

  • Women on short or antagonist protocols.
  • Women who received GnRH agonist for triggering ovulation.
  • Women who had embryo transfer.

Treatment and study plan

Cetrorelix

Drug

Primary outcomes

  1. Number of women who needed culdocentesis or paracentesis of the ascitic fluid

    Time frame: within 2 weeks of onset

Secondary outcomes

  1. Number of women who needed hospitalization

    Time frame: within 2 weeks of onset of symptoms

  2. Time to regression of nausea/vomiting

    Time frame: within 2 weeks of onset of symptoms

  3. Time to regression of large ovarian size

    Time frame: within 4 weeks of onset of symptoms

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Gonadotropin Releasing Hormone Antagonist in Treatment of Early-onset Severe Ovarian Hyperstimulation Syndrome - a Randomized Controlled Trial

Important dates

Study start
2014
Primary completion
2015
Study completion
2016
First posted
May 27, 2016
Registry last updated
May 27, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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