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OpenTrials
Completed

NCT Number: NCT02620124

GnRH Agonist as Luteal Support in FET Cycles

Back ground: A single dose of GnRH analogue in the luteal phase is reported to improve the outcome of IVF/ICSI treatments but the effect in FET cycles has not been reported.

Aim: To compare the results of frozen thawed embryo transfers with and without GnRHa analogue support Primary end point: IR, PR, on going PR Secondary end point: hCH, E2 and progesterone levels 14 days after thawing

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

20 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 20 - 45 year old women comig to frozen thawed embryo transfer

Exclusion criteria

  • The age of the woman over 42 years during the initial ICF/ICSI- treatment from which the embryos derive
  • Abnormal uterus
  • Known abnormality of karyotype of the woman or her partner
  • Severe male factor as an exclusive reason for subfertility
  • Allegy for triptorelin acetate

Treatment and study plan

Natural cycle: Triptorelin acetate 0.1 mg

Drug

A single dose of triptorelin acetate 0.1 s.c. was giwen when the age of the transferred embryo was six days in additon to standard micronized progesterone 400 mg vaginally

Hormone replacement cycle and triptorelin acetate 0.1 mg

Drug

A single dose of triptorelin acetate 0.1 s.c. was giwen when the age of the transferred embryo was six days in addition to standard Estradiol and progesterone support

Primary outcomes

  1. Pregnancy rate

    Time frame: five weeks after the embryo transfer

  2. Implantation rate

    Time frame: five weeks after the embryo transfer

  3. Ongoing pregnancy rate

    Time frame: ten weeks after the embryo transfer

Secondary outcomes

  1. hCG- level

    Time frame: 14 days after thawing of the embryos

Sponsors and collaborators

Lead sponsor

Turku University Hospital

Other Gov

Registry information

Official study title

GnRH Anonist as Luteal Support in Frozen-thawed Embryo Transfer Cycles

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Dec 2, 2015
Registry last updated
Nov 23, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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