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Completed

NCT Number: NCT02455765

Glycemic Response of Co-ingesting Carbohydrate and Amino Acids

The study will investigate if consumption of amino acid mixtures results a change in glycemic response of carbohydrate (white rice) and insulinemic response at different doses and timing (before consumption of carbohydrate).

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Key information

Conditions

Metabolic Diseases Nutritional and Metabolic Diseases

Age range

21 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

About this study

Healthy male subjects will be served with amino acid mixtures in combinations of two doses and three time points along with white rice as control. The combinations were either low or high levels of amino acid mixtures. This was consumed together or 15 min, 30 min before consumption of white rice. Postprandial blood glucose and plasma insulin concentrations were measured at fasting and every 15 min after consumption of treatment meal until 60 min after the consumption of white rice. Subsequent blood sample were taken at 30 min interval until 210min. The glucose and insulin in the blood will be analysed.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male
  • Chinese ethnicity
  • Age between 21-50 years
  • Body mass index (BMI) between 18-24.9 kg/m2
  • Waist circumference ≤ 90 cm for men
  • Normal blood pressure (<120/80 mmHg)
  • Fasting blood glucose < 6 mmol/L

Exclusion criteria

  • dislike the consumption of Essence of Chicken
  • participating in competitive sports
  • allergic to amino acids and rice
  • metabolic diseases (such as diabetes, hypertension and the metabolic syndromes)
  • Glucose-6-Phosphate-Dehydrogenase (G6PD) Deficiency
  • on prescription medication
  • smokers

Treatment and study plan

Rice and Amino Acid mixtures

Other

Rice and amino acid mixture

Primary outcomes

  1. Glycemic response

    Time frame: 210 minutes post consumption of carbohydrate

    Blood glucose will be assessed via finger prick during fasting and every 15 minutes for the first 60 min after the consumption white rice and subsequently every 30 min interval until 210 min

  2. Insulinemic response

    Time frame: 210 minutes post consumption of carbohydrate

    Plasma insulin will be assessed via finger prick during fasting and every 15 minutes for the first 60 min after the consumption white rice and subsequently every 30 min interval until 210 min

Sponsors and collaborators

Lead sponsor

Singapore Institute of Food and Biotechnology Innovation

Other Gov

Collaborators

  • Cerebos Asia Pacific Pte Ltd

Registry information

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
May 28, 2015
Registry last updated
Jan 28, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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