Hot environment
OtherParticipants exercising in a 36 degrees celsius environment
Not Yet Recruiting
NCT Number: NCT06982612
Glycemic Control Following Occupational Work in a Hot Environment
Occupational workers regularly perform physically demanding tasks in hot environments, exposing them to heat stress and potential dehydration. While the physiological impacts of heat exposure are well-documented, its effects on glycemic control remain less understood. Given the rising global temperatures due to climate change and the increasing prevalence of metabolic disorders such as obesity and type 2 diabetes, it is essential to investigate how heat exposure during work influences glycemic regulation. Understanding these interactions will help inform future occupational health guidelines and metabolic health recommendations in physically demanding industries.
Not Yet Recruiting
Trial opening soon.
Get NotifiedKey information
Age range
18 year–45 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Male or female
- Generally fit and healthy
- Participate in endurance or intermittent exercise at least 3 times a week or minimum of 150 minutes moderate intensity activity per week
Exclusion criteria
- Under 18 or 45 and over,
- any morbidity or medication that might influence carbohydrate/fat metabolism (i.e., liver/renal/cardiovascular disease) or cycling ability (musculoskeletal injury etc),
- coagulation or bleeding disorders,
- blood-borne illness,
- heart conditions,
- congenital heart disease,
- uncontrolled exercise-induced asthma,
- smoking (including vaping),
- allergies to the products used in the study,
- dieting or restrained eating behaviours.
- Females with amenorrhea would be an exclusion criteria.
Treatment and study plan
Temperate condition
OtherParticipants exercising in a 18 degrees celsius environment
Primary outcomes
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Plasma glucose
Time frame: 8hours
Measured using colorimetric assay from venous blood samples
Secondary outcomes
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Plasma insulin
Time frame: 8hours
Measured using ELISA from venous blood samples
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Plasma osmolality
Time frame: 8hours
Measured using freezing point depression from venous blood samples
-
Plasma volume change
Time frame: 8hours
Determined from haemoglobin and haematocrit measures in blood samples
-
Urine volume
Time frame: 8hours
Determined from urine samples collected before and after exercise
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Body mass
Time frame: 8hours
Determined from weighing participants before and after exercise
-
Urine specific gravity/osmolality
Time frame: 8hours
Determined from urine samples collected before and after exercise
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Rectal temperature
Time frame: 8hours
Measured via rectal probe
-
Blood pressure
Time frame: 8hours
Measured via and automated sphygmomanometer
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Respiratory gas exchanges
Time frame: 8hours
Measured via Douglas bag, gas content and volume
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Rate of perceived exertion
Time frame: 8hours
using Borg scales (from 6 [no effort] to 20 [maximal effort])
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Rate of thermal sensation
Time frame: 8hours
using -10 [cold] to +10 [hot] scale.
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Feelings of thirst, urge to urinate, GI comfort, and stomach bloatedness
Time frame: 8hours
using scales (0 = no feeling, 10 = extreme feeling)
Other outcomes
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N-back task for working memory (cognitive function)
Time frame: 8hours
The task will comprise three progressively harder memory loads (1-Back, 2-Back, 3-Back). Each stimulus type will be used in all memory loads. Participants will have to respond using the space bar when they see a stimulus that is presented one, two, or three steps previously, dependent on the load condition.
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Go/no-go task for response inhibition (cognitive function)
Time frame: 8hours
Participants will be instructed to press the space bar when a green image appears onscreen ("go" stimulus) and to inhibit responding when a red image is presented (the "no-go" stimulus). Increased commission error responses (i.e. responding incorrectly on a no-go trial) will indicate reduced response inhibition. Commission errors and correct responses will be measured as indices of performance.
-
Stroop test
Time frame: 8hours
The Stroop Test is a psychological assessment that measures a person's ability to inhibit cognitive interference and control attention. Typically, it involves naming the color of the ink in which a word is printed, even when the word itself names a different color (e.g., the word "red" printed in blue ink). The delay in response time when the word and ink color do not match-known as the Stroop effect-reflects the difficulty of suppressing automatic cognitive processes.
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Loughborough University
Other
Registry information
Important dates
- Study start
- 2025
- Primary completion
- 2026
- Study completion
- 2026
- First posted
- May 21, 2025
- Registry last updated
- May 21, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.