Glycemic Control, Brain Structure and Cognition in Youth With Type 1 Diabetes (T1DM)

LO5:

Inclusion criteria

for Participants with Type 1 Diabetes:

• Between the ages of 7 and 16
• Diagnosed with type 1 diabetes within 3 months

Inclusion criteria

for Participants without Type 1 Diabetes:

• Between the ages of 7 and 16

Exclusion criteria

for Participants with Type 1 Diabetes:

• Pregnant or lactating
• Chronic disease other than T1DM, well-controlled asthma, or Hashimoto's thyroiditis
• Other current serious medical illness
• Psychiatric illness
• Psychoactive drug dependence
• Neurological illness (except T1DM-related): stroke, seizure, major loss of consciousness, head injuries, encephalitis, or hydrocephalus, blindness, deafness
• Use of psychoactive medications or exposure to neuroleptics (except that exposures of less than 1 month, occurring more than 5 years ago, will be allowed)
• Use of dopamine depleting agents or stimulants such as Ritalin, Cylert, Adderall
• Pre-maturity at birth of more than 4 wks early with complications (e.g. on respirator at NICU)
• Inability to complete MRI scan (e.g. claustrophobia, metal implants)
• Full set (top and bottom) of orthodontic braces (Half set braces, fillings, and retainers are OK)

Exclusion criteria

for Participants without Type 1 Diabetes:

• Same as above (except cannot have type 1 diabetes)

HY5: Must have been a participant in our earlier study.