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Completed

NCT Number: NCT03646812

Glycemic and Insulinemic Response of Pasta Products in Comparison to Asian Foods

The aim of the study is to determine the glycaemic and insulinaemic index of pasta products and local foods. It is hypothesized that different pasta cuts and wholegrain composition of pasta and local foods have different GI depending on the nature of the carbohydrate content and the food structure within each food.

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Key information

Age range

21 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Clinical Nutrition Research Centre

Singapore, 117599

About this study

There will be a total of 9 test sessions and each session will last up to 3.5 hours. The order of sessions will be determined with an online randomizer. At each test session, the following procedures will be performed: two finger-prick blood samples, five minutes apart to measure baseline blood glucose and insulin concentrations Subject will be served the test food and to consume within15 minutes Following the test meal, blood samples will be collected at the following time points: 15, 30, 45, 60, 90, 120, 150 and 180min for glucose measurements and insulin measurements will be collected at 30, 60, 90, 120, 150 and 180min.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy Asian - Indian and Chinese ethnicity
  • Age between 21-40 years
  • Body mass index between 18.5 to 25 kg/m2
  • Normal blood pressure (<140/90 mmHg)
  • Fasting blood glucose < 6 mmol/L

Exclusion criteria

  • Is a current smoker
  • Is currently pregnant
  • Have any metabolic diseases (such as diabetes, hypertension etc)
  • Have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
  • Have medical conditions and/or taking medications known to affect glycemia(glucocorticoids, thyroid hormones, thiazide diuretics)
  • Have any major organ dysfunction (e.g. cardiovascular, respiratory, hepatic, renal, gastrointestinal) that may influence taste, olfaction, appetite, digestion, metabolism, absorption or elimination of test foods, nutraceutical or drug
  • Have any severe food allergy (e.g. anaphylaxis to peanuts)
  • Have any known allergies to any food components of the study protocol
  • Have active Tuberculosis (TB) or currently receiving treatment for TB
  • Have any known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
  • Is a study team member or an immediate family of any study team member. Immediate family member is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.
  • enrolled in a concurrent research study judged not to be scientifically or medically compatible with the study.
  • Have partake in sports at the competitive and/or endurance levels
  • Have intentionally restrict food intake

Treatment and study plan

Glucose Reference 1

Other

Glucose contains 50g of available carbohydrates

Glucose Reference 2

Other

Glucose contains 50g of available carbohydrates

Glucose Reference 3

Other

Glucose contains 50g of available carbohydrates

Semolina Penne

Other

Semolina Penne contains 50g of available carbohydrates

Wholegrain Penne

Other

Wholegrain Penne contains 50g of available carbohydrates

Semolina Spaghetti

Other

Semolina Spaghetti contains 50g of available carbohydrates

Wholegrain Spaghetti

Other

Wholegrain Spaghetti contains 50g of available carbohydrates

Jasmine rice

Other

Jasmine Rice contains 50g of available carbohydrates

Asian Noodles

Other

Asian Noodles contains 50g of available carbohydrates

Primary outcomes

  1. Glucose

    Time frame: up to 180 minutes

    Blood will be collected and measured using hemocue analyzer.

  2. Insulin

    Time frame: up to 180 minutes

    Blood will be collected and measured using COBAS analyzer.

Sponsors and collaborators

Lead sponsor

Singapore Institute of Food and Biotechnology Innovation

Other Gov

Collaborators

  • Barilla Singapore Pte Ltd

Registry information

Official study title

Glycemic and Insulinemic Response of Pasta Products in Comparison to Asian

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Aug 24, 2018
Registry last updated
Aug 31, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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