Glucose-dependent Insulinotropic Polypeptide (GIP) and Lipid Metabolism

The aim of this proposal is to examine whether endogenous GIP and exogenous GIP alone and in combination with insulin affect gastric emptying (GE), appetite, energy intake, energy expenditure (EE) and plasma levels of triglycerides (TAG), free fatty acids FFA) and glycerol in man.

Completed

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Key information

Conditions

Healthy Subjects

Age range

18 year–50 year

Sex eligibility

Male

Study type

Observational

Primary location

Hvidovre Hospital

Hvidovre, 2650, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Informed oral and written consent
Caucasians over the age of 18 years
Normal 75 g oral glucose tolerance test (OGTT)
Normal blood haemoglobin concentration
Normal plasma lipid profile

Exclusion criteria

First-degree relatives with diabetes and familial hypertriglyceridemia

Treatment and study plan

Incretin hormone - Glucose-dependent insulinotropic polypeptide (GIP)

Other

two different dosages:

0.8 pmol/kg/min
1.5 pmol/kg/min for 300 minutes

Sponsors and collaborators

Lead sponsor

Hvidovre University Hospital

Other

Registry information

Official study title

On the Role of Glucose-dependent Insulinotropic Polypeptide, GIP, in Postprandial Metabolism in Humans

Important dates

Study start: 2008
Primary completion: 2009
Study completion: 2009
First posted: Oct 21, 2009
Registry last updated: Oct 21, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed