Glucocorticoids With Antihistamines Versus Antihistamines in Acute Urticaria in Emergency

Acute urticaria is common and affected 12% of population. 400 patients come in department emergency of Toulouse each year and there aren't many studies in literature which evaluate the glucocorticoids treatment. Acute urticaria is pruritic and incapacitating for daily life. The standard treatment of urticaria is antihistamines H1, but glucocorticoids treatment administered orally for short course would permit to increase quickly acute urticaria uncomplicated. Clinical trial, prospective randomized double blinded of adults with acute urticaria less 24 hours duration and no take treatment urticaria before. One group randomized received 40mg of cortancyl and 1 pill of citerizine and another group randomized received 1 pill citerizine and placebo like cortancyl. Pharmacy hospital takes care of randomization. Pruritus evaluated with icth score and rash evaluated with nine rule of Wallace, the patient is evaluated in T0, one hour after and contacted by telephone at J2, J5, J15, J 21 itch score, Wallace extension, observance, side effects are asked him.

Inclusion criteria

• adults
• urticaria rash no more 24 h duration and no take treatment for urticaria

Exclusion criteria

• patients were presented severe anaphylaxis or taken antihistamines or glucocorticoids within 5 days of arrival at ED,
• severe infection
• pregnancy
• patients BPCO
• diabetics
• allergy corticosteroids
• refusal to comply
• participate an other study