Glucocorticoids Combined With Concurrent Chemoradiotherapy for Unresectable Thymoma

This study aims to assess the efficacy of methylprednisolone combined with concurrent chemoradiotherapy in treating unresectable or recurrent thymoma. Patients will receive hypofractionated radiotherapy with concurrent chemotherapy.

Methylprednisolone will be administered daily during radiotherapy at a dose of 2 mg/kg.

Inclusion criteria

• Histologically confirmed type AB or B1-3 thymoma.
• Measurable Disease: Patients must have measurable disease as defined by RECIST (Response Evaluation Criteria in Solid Tumors).
• Unresectable or recurrent thymoma, with the tumor confined to the chest and neck area.
• Between the ages of 18 and 70 years, regardless of sex.
• Eastern Cooperative Oncology Group performance status of 0 or 1.
• No prior chest radiation.
• Adequate organ Functions.
• Written informed consent obtained.

Exclusion criteria

• Contraindications to Methylprednisolone.
• History of or Concurrent Malignancy.
• Active infection, myocardial infarction within the last 6 months or symptomatic heart disease.
• Pregnant or Lactating Women.
• Bleeding Disorders.
• Recent Participation in Other Clinical Trials.
• Drug Abuse or Severe Alcoholism.
• Uncontrolled Seizures or Mental Disorders.
• Severe Allergies or Specific Sensitivities.