Glucagon Efficiency After High and Low Carbohydrate Diet

Inclusion criteria

• Age 18 - 70 years
• T1D ≥ 3 year
• BMI 20-27 kg/m2
• CSII ≥ 1 year
• HbA1c < 69 mmol/mol (8.5 %)
• C-peptide negative (< 60 pmol/l)
• Hypoglycemia awareness (self-reported)
• Use of carbohydrate counting and the insulin pump bolus calculator for all meals

Exclusion criteria

• Allergy or intolerance to lactose or Glucagen®(Novo Nordisk, Bagsværd, DK)
• Impaired renal function (eGFR < 60 ml/min/1.73m2)
• Liver disease with ALAT > 2.5 times the upper limit of the reference interval
• Use of anti-diabetic medicine (other than insulin), corticosteroids or other drugs affecting glucose metabolism during the study period or within 30 days prior to study start
• Known or suspected alcohol or drug abuse
• Other concomitant medical or psychological condition that according to the investigator's assessment makes the patient unsuitable for study participation
• Females who are pregnant, breast-feeding or intend to become pregnant or are not using adequate contraceptive methods.
• Inability to understand the patient information and to give informed consent.