IRCCs Istituto Ortopedico Rizzoli
Bologna, BO, 40136, Italy
Location status: Recruiting
Recruiting
NCT Number: NCT05357768
Global collaboRAtion on CIC-DUX4, BCOR-CCN3, High-grade Undifferentiated Round Cell Sarcoma (URCS) Project
Experimental study with biological material : case series review of clinical and histological data
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Sex eligibility
All sexes
Study type
Observational
Primary location
About this study
This is a multicenter retrospective and prospective study that will analyze all cases with a diagnosis of Undifferentiated round cell sarcomas from 01 January 1983 and all new cases referring to each participant site.
Who can participate
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Patients with undifferentiated round cell sarcomas treated from 01 January 1983 and all new patients will be included.
- Clinical and outcome information available.
- Histological slides/formalin-fixed paraffin-embedded tissue tumor blocks from archive available to perform the histology analysis/frozen tissue representative of the tumor available.
Exclusion criteria
- Diagnosis different from undifferentiated round cell sarcomas
- Patient with no clinical or outcome information available
Treatment and study plan
data collection and analysis on Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue
OtherFormalin-fixed paraffin embedded tissue and/or frozen tumoral tissue of cases negative for all Ewing's sarcoma molecular fusions, will be analyzed for the presence of CIC-DUX4 / BCOR-CCNB3 translocations fusion at each Institution.
Treatment, outcome, and prognostic factors will be related with the molecular re-classification.
Primary outcomes
-
event free survival
Time frame: baseline
Correlate clinical and pathological variables with event-free survival and overall-survival in undifferentiated round cell sarcomas.
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Istituto Ortopedico Rizzoli
Other
Registry information
Acronym: GRACefUl
Important dates
- Study start
- 2019
- Primary completion
- 2026
- Study completion
- 2028
- First posted
- May 3, 2022
- Registry last updated
- May 30, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.