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Completed

NCT Number: NCT02887417

Glioblastoma Platelet Activation Study

Glioblastoma face an increased risk of venous or arterial thromboembolism. Furthermore, the most frequent immune cells in glioblastoma are tumor associated macrophages, which find theirself in an anti-inflammatory (M2) phenotype.

Increased conjugates between circulating platelets and monocytes reflect an pro-inflammatory status.

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Key information

Conditions

Glioblastoma Astrocytoma Circulating Platelet-monocyte Conjugates Glioma Neoplasms Neoplasms by Histologic Type Neoplasms, Germ Cell and Embryonal Neoplasms, Glandular and Epithelial Neoplasms, Nerve Tissue Neoplasms, Neuroepithelial Neuroectodermal Tumors

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Neurosurgery

Greifswald, 17475, Germany

About this study

Glioblastoma face an increased risk of venous or arterial thromboembolism. Furthermore, the most frequent immune cells in glioblastoma are tumor associated macrophages, which find theirself in an anti-inflammatory (M2) phenotype.

Increased conjugates between circulating platelets and monocytes reflect an pro-inflammatory status.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • MR-morphological suspicion for glioblastoma
  • informed consent

Exclusion criteria

  • no informed consent

Treatment and study plan

Primary outcomes

  1. Mean P-selectine expression in all platelets

    Time frame: 01/ 2016 - 10/ 2016

  2. Mean CD63 expression in all platelets

    Time frame: 01/ 2016 - 10/ 2016

  3. Mean CD40 Expression in all platelets

    Time frame: 01/ 2016 - 10/ 2016

  4. Mean platelet-monocyte-conjugate formation in the monocyte population

    Time frame: 01/ 2016 - 10/ 2016

Sponsors and collaborators

Lead sponsor

University Medicine Greifswald

Other

Registry information

Acronym: GPAS

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Sep 2, 2016
Registry last updated
Aug 1, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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