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Completed

NCT Number: NCT01618318

Glasgow Asthma and Allergy Study

In the past, doctors separated people with asthma into two groups, those with "allergic asthma" (about 2/3rds of people) and those with "non-allergic asthma". These labels are not much used now as the treatments for all people with asthma don't depend on this classification. However, new treatments for asthma may become available and the classification may again become important. It could be useful for clinicians to know how to identify which patients are likely to benefit from particular treatments.

Additionally, some new blood tests are becoming available and some of these might help to categorise the type of asthma people have. What the study hopes to do is to identify patient features which make a diagnosis of "allergic asthma" more likely and to see which new blood tests are most likely to be helpful in confirming this diagnosis.

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Key information

Conditions

Asthma Allergy Bronchial Diseases Disease Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

NSHI Ltd

Dartford, Kent, DA1 5GA, United Kingdom

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male and female patients aged 18 years old and over with a diagnosis of asthma and having received at least two prescriptions for any asthma medication in the last 12 months, who have signed an informed consent form prior to initiation of any study-related procedure

Exclusion criteria

  • under 18 years
  • current smokers
  • unwilling or unable to give informed consent
  • a clinical diagnosis of COPD
  • a history of anaphylaxis (skin prick test)
  • participated in any clinical study in the last 12 months

Treatment and study plan

Primary outcomes

  1. Serum periostin level

    Time frame: 1 day

    This is a cross sectional study. Participants will be assessed and tests conducted at a single visit

Secondary outcomes

  1. skin prick test

    Time frame: 1 day

  2. Serum total IgE

    Time frame: 1 day

  3. Blood eosinophil count

    Time frame: 1 day

  4. Blood neutrophil count

    Time frame: 1 day

  5. Blood CD4 cells that are positive for CRTh2

    Time frame: 1 day

  6. Blood eosinophils expressing CRTh2

    Time frame: 1 day

  7. Spirometry

    Time frame: 1 day

Sponsors and collaborators

Lead sponsor

National Services for Health Improvement Ltd

Industry

Collaborators

  • Merck Sharp & Dohme LLC

Registry information

Official study title

Cross Sectional Study to Evaluate and Associate Clinical and Laboratory Features of People With Allergic and Non-allergic Asthma

Acronym: GLAAS

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Jun 13, 2012
Registry last updated
Dec 5, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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