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Completed

NCT Number: NCT05101434

Gingivitis and Periodontitis as a Risk Factor for Stroke

Periodontitis and gingivitis are one of the most infectious diseases in humans. Several studies have been carried out on the dependence of periodontitis and stroke. The aim of this study was to investigate gingivitis and periodontitis as risk factors for stroke in the Pakistani population.

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Key information

Conditions

Gingivitis Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Gingival Diseases Infections Mouth Diseases Nervous System Diseases Periodontal Diseases Periodontitis Stomatognathic Diseases Stroke Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Shaheed Zulfiqar Ali Bhutto Medical University

Islamabad, Capital, 44000, Pakistan

About this study

Epidemiologic studies have shown that cerebrovascular accident (CVA) is the 3rd cause of death in developed countries with 0.8 % prevalence in the whole population. Although, the prevalence rate of stroke is reduced yet is one of the most important health problems in the United State. Periodontitis and gingivitis are the two most infectious man diseases. Today, it is estimated that about 35% of people over 30-year-old in America and 50-55% of people in developing countries are involved with these diseases.

These diseases are due to the practice of chronic bacterial infection and the inflammatory response of the host. The relationship between periodontitis and CVA was first introduced by Mackenzi and Millard in 1963 but the importance of this issue was not understood. Periodontal infection can be a complex multiphase disease by associating this infection with organ systems such as cardiovascular, endocrine, reproductive, and respiratory systems. Nowadays, periodontitis is considered a risk factor for atherosclerosis and thromboembolic disease.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed stroke by using brain imaging from magnetic resonance imaging and/or computerized tomography.

Exclusion criteria

  • Not willing to participate
  • Neurological complications other than stroke

Treatment and study plan

Periodontal Probing

Diagnostic Test

with the help Michigan probe, periodontal pocket measurement was done.

Other names: ROAG revised oral assessment guide, Community periodontal index, Gingival Index

Primary outcomes

  1. Gingivitis

    Time frame: baseline

    Measurement of bleeding site while probing and this was done with gingival index

  2. Periodonitis

    Time frame: baseline

    Measurement of periodontal pockets while probing and this was done with community periodontal idex

Sponsors and collaborators

Lead sponsor

Shaheed Zulfiqar Ali Bhutto Medical University

Other

Registry information

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Nov 1, 2021
Registry last updated
Nov 1, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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