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Completed

NCT Number: NCT07706257

Gingival Unit Graft Versus Free Gingival Graft: 18-Month Digital Color Analysis

The purpose of this retrospective clinical study is to compare the long-term aesthetic integration and clinical outcomes of two periodontal plastic surgery techniques: Gingival Unit Grafting (GUG) and Free Gingival Grafting (FGG). The study evaluates the effectiveness of these procedures in increasing keratinized tissue width and assesses the color integration of the grafted tissues with the surrounding gingiva over an 18-month follow-up period using objective digital color analysis based on CIE Lab and RGB parameters.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Bezmialem Vakif University, Faculty of Dentistry

Istanbul, Fatih, 34093, Turkey (Türkiye)

About this study

This single-center retrospective study included patients treated with either Gingival Unit Grafts (GUG) or Free Gingival Grafts (FGG) for the management of Cairo Type 2 and Type 3 gingival recessions between March 2022 and December 2022. Clinical and photographic records obtained at baseline and during follow-up visits up to 18 months were retrospectively analyzed. The primary outcome was the evaluation of color integration of the grafted tissues using objective digital color analysis based on CIE Lab and RGB parameters. Secondary outcomes included changes in keratinized tissue width. The aim of the study was to compare the long-term aesthetic integration and clinical performance of GUG and FGG and to determine which technique provides superior color matching with the surrounding tissues.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Systemically healthy individuals aged between 18 and 65 years
  • No systemic diseases contraindicating periodontal surgery
  • Not taking medications known to exert adverse effects on periodontal tissues
  • Presenting with Cairo Type 2 (RT2) or Type 3 (RT3) localized gingival recessions on mandibular incisors
  • Presence of ≤1 mm of attached gingiva resulting in difficulty maintaining plaque control
  • Full-mouth plaque and gingival index scores ≤1
  • Bleeding on probing (BOP) <10%
  • No history of prior soft tissue surgery in the designated area

Exclusion criteria

  • Individuals who are pregnant or lactating.
  • Presenting with gingival recession or prosthetic restorations at the donor site (maxillary premolar palatal region).
  • Cases demonstrating caries, abrasions, or restorations on the root surfaces of the related teeth.
  • Individuals with known allergies to dental impression materials.
  • Periodontal pocket depth greater than 3 mm.
  • Tooth malposition.
  • Endodontic complications.

Treatment and study plan

Gingival Unit Grafting

Procedure

Harvesting a gingival unit graft and transplanting it to the recipient area to increase keratinized tissue width and assess long-term aesthetic integration.

Conventional Free Gingival Grafting

Procedure

Harvesting a conventional free gingival graft and transplanting it to the recipient area to increase keratinized tissue width and serve as a control group for aesthetic integration.

Primary outcomes

  1. Aesthetic Integration (Color Evaluation)

    Time frame: Baseline and 18 months post-surgery

    Objective assessment of color integration between the grafted tissue and the surrounding gingiva using digital color analysis. Color parameters were evaluated based on the CIE Lab* color space system and RGB color channels obtained from standardized clinical photographs. The degree of color matching between grafted and adjacent tissues was assessed over the follow-up period.

Secondary outcomes

  1. Keratinized Tissue Width (KTW)

    Time frame: Baseline and 18 months post-surgery

    The clinical measurement of the width of keratinized tissue in millimeters, evaluated from the gingival margin to the mucogingival junction using a standard periodontal probe to determine the amount of tissue gain.

Sponsors and collaborators

Lead sponsor

Bezmialem Vakif University

Other

Registry information

Official study title

Clinical Outcomes and Digital Color Stability of Gingival Unit Graft Versus Free Gingival Graft: An 18-Month Comparative Digital Photographic Color Analysis Study

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Jul 15, 2026
Registry last updated
Jul 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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