Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients With Chronic Periodontitis

This case control-study measures the levels of Interleukin-17 in gingival crevicular fluid and placental tissue samples of pregnant females as a possible marker in determining whether or not an association exists between chronic periodontitis and preterm labor. Interleukin-17 is a pro-inflammatory cytokine whose levels have been proven to increase in periodontal disease.

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Key information

Conditions

Chronic Periodontitis Chronic Disease Disease Attributes Female Urogenital Diseases and Pregnancy Complications Mouth Diseases Obstetric Labor Complications Obstetric Labor, Premature Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Pregnancy Complications Premature Birth Preterm Labor Stomatognathic Diseases Urogenital Diseases

Age range

18 year–35 year

Sex eligibility

Female

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Within the age range of 18-35 years
Free of any systemic diseases as referenced from Burket's Oral Medicine health history questionnaire (Glick2008)
Spontaneous normal term birth at ≥37 weeks of gestation without any obstetrical or medical complications
Spontaneous preterm birth (PTB) at <37 weeks of gestation after uterine contraction or rupture of membranes (Keelan1999)

Exclusion criteria

History of medications that may affect the study outcome, such as: current use of systemic corticosteroids or antibiotics for at least one month
Genital and urinary tract infections
Existing hypertension and diabetes mellitus before pregnancy, autoimmune disease, asthma, and chronic renal disease
Multiple pregnancies, cervical cerculage, abnormal placentation, past history of preterm delivery, or antepartum hemorrhage
Low or high maternal body mass index

Treatment and study plan

Primary outcomes

Interleukin-17

Time frame: Single sample from each patient following birth

Interleukin-17 levels in gingival crevicular fluid and placental tissue samples

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Important dates

Study start: 2014
Primary completion: 2015
Study completion: 2015
First posted: May 31, 2017
Registry last updated: Jul 24, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed