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NCT Number: NCT05142124

German Cardiac Arrest Registry

In Germany, 70.000 to 100.000 patients suffer from out-of-hospital cardiac arrest (OHCA) every year. More than half of these are due to cardiac causes. Despite the medical progress over the last decades, rates of survival with good neurological outcome remain low. For many below-mentioned issues, no adequate evidence from randomized trials is available. Therefore, a systematic and standardized recording of the pre-clinical, clinical and post-clinical treatment course and of the clinical outcomes of OHCA patients is essential to improve patient care. Aim of the German Cardiac Arrest Registry (G-CAR) is to achieve a better understanding of the disease entity, leading to an optimized treatment of OHCA patients. The recorded data include information on demographic and psychosocial aspects, course of the disease, clinical, laboratory and other examinations as well as treatment modalities in patients with OHCA due to a cardiac cause.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHARITE - Universitätsmedizin Berlin - Campus Virchow Klinikum, Berlin, State of Berlin, Germany

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with out-of-hospital cardiac arrest with assumed cardiovascular cause

Exclusion criteria

  • rejection of register participation by patient or legal representative

Treatment and study plan

Primary outcomes

  1. In hospital mortality

    Time frame: until discharge, an average of 2 weeks

Secondary outcomes

  1. Length of ICU stay

    Time frame: until discharge, an average of 2 weeks

  2. Length of hospital stay

    Time frame: until discharge, an average of 2 weeks

  3. Mortality

    Time frame: Day 30

  4. Mortality

    Time frame: Month 6

  5. European Quality of Life 5 Dimensions 5 Level Version (EQ-5D)

    Time frame: Month 6

    five levels in each dimension are worded as (1) 'not /no problems', (2) 'slight problems', (3) 'moderate problems', (4) 'severe problems', and (5) 'unable to'

  6. Post Traumatic Stress Syndrome

    Time frame: Month 6

    PTSS-14

  7. Reintegration

    Time frame: Month 6

    Reintegration to Normal Living Index

  8. Hospital Anxiety and Depression Scale (HADS)

    Time frame: Month 6

    score 0-21; higher value show more severe depression

  9. Mini Montreal Cognitive Assessment (MoCA)

    Time frame: Month 6

    score 0-15; 11 or higher is normal, 10 or less indicate cognitive dysfunction

  10. Mini Montreal Cognitive Assessment (MoCA)

    Time frame: Month 12

    score 0-15; 11 or higher is normal, 10 or less indicate cognitive dysfunction

  11. Mortality

    Time frame: Month 12

  12. European Quality of Life 5 Dimensions 5 Level Version (EQ-5D)

    Time frame: Month 12

    five levels in each dimension are worded as (1) 'not /no problems', (2) 'slight problems', (3) 'moderate problems', (4) 'severe problems', and (5) 'unable to'

  13. Post Traumatic Stress Syndrome (PTSS-14)

    Time frame: Month 12

    scor 14-98; higher value indicate more post traumatic stress

  14. Reintegration

    Time frame: Month 12

    Reintegration to Normal Living Index

  15. Hospital Anxiety and Depression Scale (HADS)

    Time frame: Month 12

    score 0-21; higher value indicate more severe depression

Study contacts

Contact information is provided by the study sponsor or research team.

Holger Thiele, Prof.

CONTACT

[email protected]

+49 341 865 ext. 1428

Janine Pöss, Dr.

CONTACT

[email protected]

+49 341 865 ext. 1428

Sponsors and collaborators

Lead sponsor

Leipzig Heart Science gGmbH

Other

Collaborators

  • Charite University, Berlin, Germany
  • Heart Center Leipzig - University Hospital
  • Helios Health Institute GmbH
  • IHF GmbH - Institut für Herzinfarktforschung
  • Klinikum Ludwigshafen
  • St. Antonius Hospital
  • University Hospital of Cologne
  • University of Magdeburg
  • Universitätsklinikum Hamburg-Eppendorf

Registry information

Acronym: G-CAR

Important dates

Study start
2021
Primary completion
2026
Study completion
2027
First posted
Dec 2, 2021
Registry last updated
Feb 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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