Genomics, Single Nucleotide Polymorphisms (SNPs), and Clinical Neonatology

Key information

Conditions

Lung Disease Brain Diseases Brain Injuries Brain Injury Central Nervous System Diseases Craniocerebral Trauma Digestive System Diseases Enterocolitis Enterocolitis, Necrotizing Gastroenteritis Gastrointestinal Diseases Intestinal Diseases Lung Diseases Necrotizing Enterocolitis Nervous System Diseases Respiration Disorders Respiratory Failure Respiratory Insufficiency Respiratory Tract Diseases Trauma, Nervous System Wounds and Injuries

Sex eligibility

All sexes

Study type

Observational

Primary location

Children's Mercy Hospitals and Clinics, Kansas City, Missouri, United States

About this study

This genetic predisposition study does not involve investigational drugs, devices, or treatments. Our broad goal is to identify genomic factors, which contribute to the development or exacerbation of common and critical illnesses that affect preterm and near-term infants. We seek to accomplish this goal in the following ways:

First: to test candidate gene DNA variations and link already identified single nucleotide polymorphisms (SNPs) producing functional alterations to the risk of clinically important disorders.
Second: to utilize a whole-genomic approach to identify SNPs not previously linked to the risk of development or progression of neonatal disorders.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Less than 34 weeks gestation and less than 1500 g at birth
Greater than or equal to 36 weeks gestation and either with hypoxic respiratory failure or with mild respiratory distress never requiring assisted ventilation

Exclusion criteria

Life threatening anomalies of any organ system (e.g., cardiac, thoracic, lethal, or non-lethal chromosomal abnormalities)

Sponsors and collaborators

Lead sponsor

Children's Mercy Hospital Kansas City

Other

Collaborators

University of Kansas

Registry information

Official study title

Genomics, SNPs, and Clinical Neonatology

Important dates

Study start: 2006
Primary completion: 2008
Study completion: 2011
First posted: Apr 18, 2006
Registry last updated: Aug 26, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed