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Recruiting

NCT Number: NCT06042387

Genome Analysis Across Populations in Inflammatory Bowel Disease

Objective:

To use clinical, genetic and genome analysis to better understand and define the genetic and environmental factors that contribute to IBD within affected populations.

Recruiting

Interested in participating?

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Key information

Conditions

Ulcerative Colitis Colitis Colitis, Ulcerative Colonic Diseases Crohn Disease Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Healthy Inflammatory Bowel Diseases Intestinal Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

Background:

Inflammatory bowel disease (IBD) is a chronic, and often disabling, disorder of the intestines characterized by dysregulation of mucosal immune response. Recent data suggests that the incidence and prevalence rates among all populations may be increasing due to constantly changing environmental exposures. The goal of the study is to identify susceptible genes that contribute to the pathogenesis of IBD in affected individuals.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects: diagnosed with Inflammatory Bowel Disease (Crohn's disease, ulcerative colitis, IBD-undetermined)
  • Available medical records to confirm IBD diagnosis (Crohn's disease, Ulcerative colitis, IBD undetermined (IBD-U))
  • Healthy controls: no personal history of IBD, no family history of IBD, no history of unexplained chronic diarrhea/blood in stool/anemia/abdominal pain/weight loss
  • Any age

Exclusion criteria

  • Subjects with other gastrointestinal conditions not meeting the above IBD or Healthy Control criteria

Treatment and study plan

Blood or saliva sample collection

Genetic

Blood or saliva sample & clinical data collection

Primary outcomes

  1. Genomics studies across populations

    Time frame: 2022-2027

    Whole Exome Sequencing (+/- other sequencing) is planned

Study contacts

Contact information is provided by the study sponsor or research team.

Jenny Lee, MKin

CONTACT

[email protected]

416-586-4800 ext. 2318

Joanne Stempak, MSc

CONTACT

[email protected]

4165864800 ext. 8399

Sponsors and collaborators

Lead sponsor

Mount Sinai Hospital, Canada

Other

Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Registry information

Important dates

Study start
2022
Primary completion
2027
Study completion
2027
First posted
Sep 18, 2023
Registry last updated
Mar 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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