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NCT Number: NCT05561881

Genicular Nerve Block Versus IPACK Block for Knee Arthroscopic Surgery

Postoperative pain management after knee arthroscopic surgery continues to evolve with better treatment strategies being formulated to improve patient satisfaction, and clinical outcomes and reduce opioid use in the immediate postoperative period. appropriate perioperative pain management has been shown to result in faster recovery and rehabilitation leading to better functional outcomes in patients undergoing knee arthroscopic surgery. this has necessitated the development of multimodal analgesics. peripheral nerve blockade has been reported to deliver optimal postoperative pain relief and is increasingly preferred in patients undergoing arthroscopic procedures and various different techniques such as sciatic nerve block, femoral nerve block, and genicular block have been described.

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Key information

Conditions

Genicular Nerve Block

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Assiut University

Asyut, Asyut Governorate, Egypt

About this study

The genicular nerves include branches from the femoral, common peroneal, saphenous, tibial, and obturator nerves which innervate the knee capsule. the superolateral, superomedial, and inferomedial branches of the genicular nerve were reported to be in proximity to the periosteum of the tibia and femur, and the superolateral, inferolateral, superomedial, and inferomedial quadrant of the anterior knee joint were shown to be innervated by superior lateral, inferior lateral, superior medial and inferior medial branches of the genicular nerve, respectively alongside the branches of peroneal and femoral nerves Thus, a genicular nerve block specifically Targets these branches which innervate the knee joint for the management of postoperative pain in arthroscopic surgery.

On the other hand, the interspace between the popliteal artery and capsule of the knee(IPACK) block provides analgesia on the posterior knee joint, and the application of a genicular or IPACK block has been proven to be associated with promising outcomes following arthroscopic surgery

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age 20_60 years
  • American Society of anthologist class I-III
  • BMI18_35 kg/m2
  • scheduled for primary unilateral knee arthroscopic surgery

Exclusion criteria

  • known allergy to local anesthesia
  • contraindication to local anesthesia injection (e.g., infection at the site of injection
  • contraindication to spinal anesthesia (e.g., coagulopathy)
  • patients with preexisting motor or sensory deficit in lower extremities
  • insulin or non-insulin-dependent diabetes mellitus
  • systemic corticosteroids use within 30 days
  • history of arrhythmia or seizures
  • severe renal insufficiency
  • patient refusal

Treatment and study plan

popliteal artery and the capsule of the posterior knee (IPACK) block

Other

ultra-sound visualization of the popliteal artery and posterior surface of the distal femur then the image of the femoral condyles and popliteal artery will be obtained. A needle with a tip length of 100 mm will be inserted in a medial to the lateral plane parallel to the femur in the middle area between the popliteal artery and femur,20 ml local anesthetic solution will be given into this space with adequate and equal distribution of anesthetic agent

genicular nerves block

Other

ultra-sound transducer placed parallel to the femur shaft and the epicondyle will be identified, the superomedial superolateral and inferomedial genicular arteries, which follow a similar route with each genicular nerve will be visualized close to the periosteal areas, A20G needle with a tip length of 50mm will be directed in the plane of the US probe in the long axis view. After confirming placing of the needle next to each genicular artery a total amount of 20 ml local anesthetic in equal increments at multiple sites.

Primary outcomes

  1. Pain Visual Analogue Scale (VAS)

    Time frame: first postoperative 24 hours

    VAS in the first postoperative 24 hours

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Comparison of Efficacy Between Ultra-sound Genicular Nerve Block Versus the Popliteal Artery and the Capsule of the Posterior Knee(IPACK) Block for Knee Arthroscopic Surgery

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
Sep 30, 2022
Registry last updated
Oct 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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