Genetics and Mechanisms of Rheumatoid Arthritis

The study is aimed at revealing genetic background in rheumatoid arthritis (RA). For that purpose samples of DNA will be collected from 500 RA patients and similar number of controls from whole Slovakia. Variations in several genes associated with RA will be evaluated. The second aim is to assess functional changes in immune cells from selected patients and their evaluation together with genetic background. The project has observational character without any intention to change the treatment of RA patients.

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Key information

Conditions

Rheumatoid Arthritis Arthritis Arthritis, Rheumatoid Autoimmune Diseases Connective Tissue Diseases Genetic Association Studies Immune System Diseases Joint Diseases Leukocytes, Mononuclear Musculoskeletal Diseases Rheumatic Diseases Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Slovak Academy of Sciences, Center for Molecular Medicine

Bratislava, 83101, Slovakia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

rheumatoid arthritis or healthy

Exclusion criteria

Treatment and study plan

Primary outcomes

Genetic association

Time frame: 1 day

Association of selected single nucleotide polymorphisms with rheumatoid arthritis.

Secondary outcomes

Peripheral blood mononuclear cells reactivity

Time frame: 1 day

Reactivity and functional changes of peripheral blood mononuclear cells obtained from patients with rheumatoid arthritis in comparison to healthy controls.

Sponsors and collaborators

Lead sponsor

Slovak Academy of Sciences

Other Gov

Registry information

Official study title

Rheumatoid Arthritis Susceptibility Genes in Austrian and Slovak Population

Acronym: RASGENAS

Important dates

Study start: 2009
Primary completion: 2012
Study completion: 2012
First posted: Feb 11, 2013
Registry last updated: Feb 11, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed