Genetic Variability in Taste Perception

This proposal describes a pilot study aimed at determining whether genetic variations in taste receptors determine differential taste tolerability of pediatric medications.

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Key information

Conditions

Healthy

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

Monell Chemical Senses Center

Philadelphia, Pennsylvania, 19104, United States

About this study

This is a cross-sectional call-back study of taste perception and the relationship between taste perception and taste receptor genotype.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult females who were previously enrolled in Efficacy of Bitter Blockers on Taste Acceptance in Pediatric Populations Study (Protocol #809789)

Exclusion criteria

Women who are pregnant
Women on drugs with potential serious adverse effects that are mediated through cytochrome P450.

Treatment and study plan

Primary outcomes

Psychophysical data for taste solutions

Time frame: 1-2 hours

Primary outcome variables are intensity ratings of pediatric medications as well as a variety of generally recognized as safe bitter and non-bitter compounds.

Secondary outcomes

Maternal practices and perceptions of medication use

Time frame: 1-2 hours

Secondary outcome variables include questions related to maternal practices and perceptions of medication use and compliance of their children.

Sponsors and collaborators

Lead sponsor

Monell Chemical Senses Center

Other

Collaborators

Children's Hospital of Philadelphia
National Institute on Deafness and Other Communication Disorders (NIDCD)
University of Pennsylvania

Registry information

Important dates

Study start: 2012
Primary completion: 2015
Study completion: 2015
First posted: Apr 26, 2013
Registry last updated: Mar 16, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed