Genetic Susceptibility to Lung Cancer in Never Smokers

The purpose of this study is to help us better understand the cellular changes that may lead to the development of lung cancer. We want to compare people who have never smoked and yet have been diagnosed with lung cancer to never smokers who have not developed lung cancer. We hope to use the information obtained in this study as the basis for future studies and will not regard the results from this study as final.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Lung Cancer Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Sex eligibility

All sexes

Study type

Observational

Primary location

Memorial Sloan-Kettering Cancer Center

New York, 10065, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Cases will be eligible for inclusion if:
They have been diagnosed with a lung cancer or have had previous surgical treatment for their lung cancer and have smoked fewer than 100 cigarettes in their lifetime, are/were not regular cigar or pipe smokers, and
They have had no prior chemotherapy or radiation treatment within the last year (Exception: genotyping analysis/screening can be performed on specimens from individuals who had chemo/radiation treatment within the last year as germline DNA will not be affected)
They speak and read English
They understand and agree to sign informed consent, and
They agree to give us a blood sample, and
They agree to complete the study questionnaire, and
They agree to have their pathology information reviewed by study personnel.
Controls will be eligible for inclusion if:
They have not been diagnosed with any type of cancer, exclusive of nonmelanoma skin cancer and have smoked fewer than 100 cigarettes in their lifetime, are/were not regular cigar or pipe smokers, and
They speak and read English
They understand and agree to sign informed consent, and
They agree to give us a blood sample, and
They agree to complete the study questionnaire.

Exclusion criteria

Subjects who do not meet the inclusion criteria for either the case or control groups will not be eligible for this study.
All individuals who otherwise meet the eligibility requirements above, but who have had chemotherapy or radiation therapy within 1 year of evaluation will be excluded (Exception: genotyping analysis/screening can be performed on specimens from individuals who had chemo/radiation treatment within the last year as germline DNA will not be affected).

Treatment and study plan

Questionaire, blood sample

Behavioral

Provide 30ml blood for laboratory assays Complete Health Questionnaire

Primary outcomes

To evaluate germline genetic variants and their association with lung cancer in never smokers.

Time frame: conclusion of study

Secondary outcomes

To evaluate whether overall DNA damage/repair capacity is associated with lung cancer in never smokers.

Time frame: conclusion of study

Sponsors and collaborators

Lead sponsor

Memorial Sloan Kettering Cancer Center

Other

Registry information

Important dates

Study start: 2005
Primary completion: 2027
Study completion: 2027
First posted: Jan 18, 2008
Registry last updated: Jun 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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