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NCT Number: NCT04906863

Genetic Studies of Early-onset Dementia

The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.

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Key information

Conditions

Dementia, Early Onset Alzheimer Dementia (AD) Alzheimer Disease Brain Diseases Central Nervous System Diseases Cognition Disorders Cognitive Dysfunction Dementia Memory Disorders Memory Loss Mental Disorders Mild Cognitive Impairment (MCI) Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurodegenerative Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Tauopathies

Age range

35 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Columbia University Irving Medical Center

New York, 10032, United States

Location status: Recruiting

Location contact

Christiane Reitz, MD PhD

PRINCIPAL_INVESTIGATOR

Pamela del Rosario, MD

CONTACT

[email protected]

212-304-7284

About this study

The study population includes individuals with Alzheimer's disease, mild cognitive impairment, other forms of dementia, as well as cognitively healthy individuals with a family history of dementia. Participants include males and females across all racial and ethnic groups.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 35 years and older
  • Individuals experiencing memory concerns or diagnosed with dementia and their family members that are unrelated healthy controls without dementia.

Exclusion criteria

  • Individuals with competing diagnosis such as Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc., unless family members of a dementia affected individual

Treatment and study plan

Blood Draw

Genetic

Blood draw for identification of genetic variants associated with the development of memory problems

Neurocognitive Testing

Other

Brief memory test

Medical questionnaire

Other

Collection of medical history

Primary outcomes

  1. Genetic risk variants associated with early-onset dementia

    Time frame: 2 years

    Genetic factors will be measured through genome-wide genotyping arrays and/or whole-genome sequencing, and then correlated with Alzheimer disease and related phenotypes, such as cognitive impairment, functional impairment, and relevant biomarkers.

  2. Changes in blood biomarkers in early-onset dementia

    Time frame: 2 years

    Blood biomarkers including plasma amyloid beta and tau protein will be assessed in blood and correlated with onset and progression of memory loss and functional impairment

Study contacts

Contact information is provided by the study sponsor or research team.

Pamela Del Rosario

CONTACT

[email protected]

212-304-7284

Sponsors and collaborators

Lead sponsor

Columbia University

Other

Collaborators

  • National Institute on Aging (NIA)
  • University of Miami

Registry information

Important dates

Study start
2016
Primary completion
2028
Study completion
2028
First posted
May 28, 2021
Registry last updated
Apr 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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