Skip to main content
OpenTrials
Completed

NCT Number: NCT04680013

Genetic Studies in Familial Dementia

The purpose of this study is to identify genetic factors that contribute to or cause dementia (loss of memory) and related disorders across all ages and ethnic groups. This includes a number of neurological diseases such as early and late-onset Alzheimer disease, mild cognitive impairment, and other dementias.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Dementia of Alzheimer Type Alzheimer Disease Alzheimer Disease, Early Onset Alzheimer Disease, Late Onset Brain Diseases Central Nervous System Diseases Cognition Disorders Cognitive Dysfunction Dementia Memory Disorders Mental Disorders Mild Cognitive Impairment Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurodegenerative Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Tauopathies

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Miami

Miami, Florida, 33136, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years and older
  • Patients diagnosed with dementia, their family members and unrelated healthy controls without dementia.

Exclusion criteria

  • Individuals with competing diagnosis such as: Amyotrophic lateral sclerosis, Frontotemporal lobar degeneration, Multiple system atrophy, Corticobasal degeneration, Progressive Supranuclear Palsy, Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc. (unless family members of a dementia affected individual).

Treatment and study plan

Primary outcomes

  1. Correlation between genetic factors and Alzheimer disease, dementia, and related phenotypes.

    Time frame: 5 years

    Genetic factors will be measured through genome-wide genotyping arrays and/or whole-genome sequencing, and then correlated with Alzheimer disease and related phenotypes, such as cognitive impairment, functional impairment, and relevant biomarkers.

    .

Sponsors and collaborators

Lead sponsor

University of Miami

Other

Collaborators

  • Case Western Reserve University
  • Columbia University
  • National Institute on Aging (NIA)
  • Wake Forest University

Registry information

Important dates

Study start
2007
Primary completion
2024
Study completion
2024
First posted
Dec 22, 2020
Registry last updated
Mar 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.