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Completed

NCT Number: NCT00069472

Genetic Registry for Rheumatoid Arthritis

Many genes are thought to contribute to rheumatoid arthritis (RA). This study will attempt to identify genes that may contribute to RA.

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Key information

Conditions

Rheumatoid Arthritis Arthritis Arthritis, Rheumatoid Autoimmune Diseases Connective Tissue Diseases Immune System Diseases Joint Diseases Musculoskeletal Diseases Rheumatic Diseases Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Feinstein Institute for Medical Research

Manhasset, New York, 11030, United States

About this study

The identification of genes for complex disorders such as RA requires large numbers of genetically informative families. This study enrolls people diagnosed with with RA and their families.

This study will enroll 1000 RA patients and their parents. Participants with RA will be evaluated at his or her doctor's office or other location convenient for the participant. Participants will have a brief phone interview with a study coordinator and a blood sample will be obtained. Disease evaluation will be done at one visit and will include confirmation of diagnosis, a 28 joint count, joint alignment and mobility score (JAMS) and administration of a health assessment questionnaire.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult onset RA
  • Diagnosis of RA made between 18 and 60 years old
  • Both parents alive and willing to participate
  • Parents may have diagnosis of RA (affected) or be unaffected

Exclusion criteria

  • Inflammatory bowel disease
  • Lupus
  • Psoriatic arthritis

Treatment and study plan

Primary outcomes

  1. Genetic Association with risk for rheumatoid arthritis

    Time frame: 10 years

    The project aims to identify risk alleles for rheumatoid arthritis using association methods in trio families, combined with data from singleton cases and multiplex families

Sponsors and collaborators

Lead sponsor

Northwell Health

Other

Collaborators

  • Arthritis Foundation
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Registry information

Official study title

Genetics of Rheumatoid Arthritis Registry

Acronym: NARAC

Important dates

Study start
2002
Primary completion
2015
Study completion
2015
First posted
Sep 29, 2003
Registry last updated
Sep 10, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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