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Completed

NCT Number: NCT02955407

Genetic Predisposition for Chronic Non-specific Low Back Pain

Patients with inflammatory back pain were shown to differ from healthy controls in genotype of the Angiotensin-converting enzyme (ACE), which regulates vasoconstriction/-dilatation. The aim of this study is to investigate whether genetic reduction of muscle perfusion might be a pathophysiological pathway of how genes influence chronic non-specific low back pain (LBP).

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Key information

Conditions

Low Back Pain Back Pain Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Balgrist University Hospital

Zurich, 8008, Switzerland

About this study

The following genes will be investigated:

  • Insertions-/deletions-polymorphism of the angiotensin-converting enzyme (ACE-I/D gene polymorphism; 3 genotypes: ACE-II, ACE-ID, ACE-DD).
  • Anti-adhesive extracellular matrix protein Tenascin-C: gene polymorphism rs2104772

The goals of this study are to investigate whether these genotypes correlate with 1) endurance of back muscles, 2) comorbidities such as asthma and diabetes and 3) the risk for LBP as assessed by a LBP-classification tool.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-65

Exclusion criteria

  • Spinal surgery
  • Spinal fracture
  • Inflammation
  • Tumour
  • Severe chronic disease which make intensive physical activity impossible (osteoporosis, cardiovascular heart diseases)

Treatment and study plan

No intervention

Other

observational case-control study

Primary outcomes

  1. Polymorphism ACE Gene

    Time frame: baseline

  2. Polymorphism Tenascin Gene

    Time frame: baseline

Secondary outcomes

  1. Back muscle endurance in Sorensen test

    Time frame: baseline

Sponsors and collaborators

Lead sponsor

Balgrist University Hospital

Other

Registry information

Official study title

Genetic Predisposition for Reduced Back Muscle Strength and Back Muscle Endurance in Patients With Chronic Non-specific Low Back Pain

Acronym: Backgene

Important dates

Study start
2016
Primary completion
2018
Study completion
2018
First posted
Nov 4, 2016
Registry last updated
Jan 23, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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