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NCT Number: NCT06763198

Genetic Polymorphisms Associated With the Risk of Pancreatitis in Patients With Alcohol Related Cirrhosis.

Alcohol is a known risk factor for both pancreatitis and cirrhosis. However, not all patients with alcohol related cirrhosis develop pancreatitis. It is not known which patients with alcohol-related cirrhosis develop symptomatic or clinically inapparent pancreatitis (Acute or Chronic Pancreatitis).There is no data whether genetic polymorphisms predispose patients with alcohol-related cirrhosis to additional pancreatic injury. There is no data on the spectrum of clinical and subclinical pancreatic changes (structural and functional) in patients with alcohol-related cirrhosis, and their genotypic correlates.This study aims to determine pancreatitis-related gene variants among patients with alcohol-related cirrhosis, with and without pancreatitis. We also aim to study differences in nutritional and functional parameters among alcoholic cirrhosis with and without chronic pancreatitis and also define the relationship of genetic polymorphisms with the pancreatic phenotype. Consecutive patients with alcohol related cirrhosis will be screened for changes of pancreatitis on CT/MR/EUS. Those with and without pancreatitis will be compared with respect to demographic, clinical, genotype, nutritional status .We will also be including a group of MAFLD/Cryptogenic cirrhosis for genotypic and phenotypic comparison.

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Key information

Conditions

Alcohol-related Liver Disease

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Institute of Liver & Biliary Sciences (ILBS)

New Delhi, National Capital Territory of Delhi, 110070, India

Location contact

Dr Aakula Suguna Sree, MD

CONTACT

[email protected]

01146300000

About this study

Aim and Objective - To determine pancreatitis-related gene variants among patients with alcohol-related cirrhosis, with and without pancreatitis.

Primary objective: To determine the genetic variants associated with morphological and functional pancreatic changes among patients with alcohol-related cirrhosis.

Secondary objectives

  • To define the relationship of genetic polymorphisms with the pancreatic phenotype.*
  • To study differences in nutritional and functional parameters among alcoholic cirrhosis with and without chronic pancreatitis.

Hypothesis -

  • Genetic polymorphisms related to pancreatitis predispose patients with alcohol-related cirrhosis to additional pancreatic injury.

Associated chronic pancreatitis (clinically apparent or subclinical) negatively influences the nutritional and functional status of patients with alcohol-related cirrhosis

  • Study design: Cross sectional study of two study cohorts
  • Study period: 1 year.
  • Sample size with justification: Studies have reported pathogenic SPINK 1 mutations in 25% -50.0% among idiopathic CP and 10-20% in acute pancreatitis as compared to 1%-4.7% among controls. The investigator assume pathogenic SPINK 1 mutation frequency of 50% and 1% among alcohol-related cirrhosis with and without CP, respectively. The investigator also assume a 33% prevalence of CP among alcohol-related cirrhosis. With significance (α) at 0.5, power of 80%, investigator need to enroll 100 patients of alcohol-related cirrhosis.The investigator will also include a cohort of 50 males with cirrhosis of other etiologies.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients > 18 years of age.
  • Alcohol-related cirrhosis
  • Males

Exclusion criteria

  • Current Hepatic encephalopathy or cognitive dysfunction precluding adequate nutritional and functional assessment.
  • HCC.
  • Complete or partial PVT.
  • Significant cardio-pulmonary comorbidity
  • Patients who do not consent for genetic study
  • Inability to provide informed consent.
  • Cannot understand Hindi or English should be excluded since they will not be able to reply objectively to questionnaire.

Treatment and study plan

Primary outcomes

  1. Genetic polymorphisms in one or more pancreatitis-associated genes* among patients with alcohol-related cirrhosis, with and without pancreatitis.

    Time frame: Day 0

Secondary outcomes

  1. Differences in genetic polymorphisms in one or more pancreatitis related genes in patients with pancreatitis between alcohol related cirrhosis and cirrhosis of other etiologies.

    Time frame: Day 0

  2. To define the relationship of genetic polymorphisms with the pancreatic phenotype.*

    Time frame: Day 0

  3. Prevalence of pancreatitis defined by CT/MR/EUS among patients with alcohol-related cirrhosis.

    Time frame: Day 0

  4. Difference in prevalence of pancreatitis defined by CT/MR/EUS among patients with alcohol-related cirrhosis and cirrhosis of other etiologies .

    Time frame: Day 0

  5. Severe exocrine insufficiency defined by fecal elastase <100µg/g stool among cirrhotic patients with and without chronic pancreatitis

    Time frame: Day 0

  6. Endocrine insufficiency defined by FBS >126mg/dl and HbA1c >6.5% among cirrhotic patients with and without chronic pancreatitis.

    Time frame: Day 0

  7. Sarcopenia defined by Skeletal muscle index of < 50cm/m2 in men on CT, and/or 7.0 kg/m2 on DEXA among cirrhotic patients with and without chronic pancreatitis.

    Time frame: Day 0

  8. Liver frailty index > 4.5

    Time frame: Day 0

Study contacts

Contact information is provided by the study sponsor or research team.

Dr Aakula Suguna Sree, MD

CONTACT

[email protected]

01146300000

Prof. Vikram Bhatia, DM

CONTACT

[email protected]

01146300000

Sponsors and collaborators

Lead sponsor

Institute of Liver and Biliary Sciences, India

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jan 8, 2025
Registry last updated
Jan 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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