Genetic Modifiers of Cystic Fibrosis Related Diabetes

This research is being done to find the genes and other factors that are responsible for differences among persons with cystic fibrosis. We are particularly interested in the factors that relate to the development of Cystic Fibrosis Related Diabetes (CFRD).

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Key information

Conditions

Cystic Fibrosis Related Diabetes Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

3 month–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Children's Memorial Hospital, Chicago, Illinois, United States

About this study

The study is recruiting people with cystic fibrosis (CF). The medical record is being extracted, and a blood sample is taken for DNA. The DNA samples are tested for variation both at the cystic fibrosis transmembrane conductance regulator (CFTR) gene (the CF gene) and over the entire rest of the genome. Using large numbers of people with CF, and knowing who does and does not have CFRD, we identify genetic variations that associate with CFRD. Knowing these variations allows us to better understand the causes of CFRD, and with enough information, better to predict CFRD and identify people at particularly high or low risk of CFRD. People participating in this study also have the option to participate in related studies of other metabolic traits in CF such as over- and underweight.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Any person with Cystic Fibrosis and his/her parents.

Exclusion criteria

None

Treatment and study plan

Primary outcomes

Identification of Genes or other factors that influence the development of CFRD

Time frame: 5 years

Sponsors and collaborators

Lead sponsor

Johns Hopkins University

Other

Collaborators

Cystic Fibrosis Foundation
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Northwestern University
University of Minnesota

Registry information

Important dates

Study start: 2008
Primary completion: 2030
Study completion: 2030
First posted: Apr 29, 2010
Registry last updated: Apr 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed