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Completed

NCT Number: NCT00161161

Genetic Liability in the Brain Morphology of Attention Deficit Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder (ADHD) is a heritable psychiatric disorder with onset in childhood. Twin and adoption studies indicate that additive genetic factors explain up to 80% of the variance underlying susceptibility. The siblings of children with ADHD have a three- to fivefold increased risk of having ADHD compared to the siblings of healthy control subjects, and the risk is even greater for monozygotic twins with 50-80% concordance compared with up to 33% in dizygotic twins). As full siblings share on average 50% of their genes, even the unaffected siblings of children with ADHD would be expected to share some of the genes involved in the disorder. The neuroanatomical substrate of ADHD is becoming increasingly better defined by a growing body of evidence from imaging studies. Evidence from neuroimaging studies suggests that this disorder is associated with reductions in brain volume up to 5% in these children. In this protocol we collected MRI-scans from boys with ADHD and their unaffected siblings, as well as control subjects. In addition, cheekswabs were later collected for DNA analysis.

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Key information

Conditions

Attention Deficit Hyperactivity Disorder Attention Deficit Disorder with Hyperactivity Attention Deficit and Disruptive Behavior Disorders Mental Disorders Neurodevelopmental Disorders

Age range

7 year–18 year

Sex eligibility

Male

Study type

Observational

Primary location

UMC Utrecht

Utrecht, 3584CX, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age 7 - 18 years.

Inclusion criteria

for patients

  • DSM-IV (APA, 1994) diagnosis of ADHD (combined subtype), according to DISC interview
  • scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
  • one brother who meets the inclusion criteria for siblings

Inclusion criteria

for siblings

  • no DSM-IV (APA,1994) diagnosis for ADHD or another disruptive disorder (ODD or CD), according to DISC interview
  • no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)

Inclusion criteria

for controls

  • no DSM-IV (APA, 1994) diagnosis, according to DISC interview
  • no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)

Exclusion criteria

  • IQ < 70
  • illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
  • the presence of metal objects in or around the body (pacemaker, dental braces)

Sponsors and collaborators

Lead sponsor

UMC Utrecht

Other

Collaborators

  • The Dutch Brain Foundation

Registry information

Important dates

Study start
1999
Study completion
2002
First posted
Sep 12, 2005
Registry last updated
Dec 30, 2005

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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