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NCT Number: NCT06740136

Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS)

The objective of this study is to evaluate the association between the evolution of plasma CPK levels and genetic polymorphisms, both before the muscle-damaging exercise and at three post-exercise time points. The investigators aim to include 300 participants in this research.

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Key information

Conditions

Healthy Behavior Motor Activity

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Elite-level sports expose athletes to training loads designed to induce muscle damage, aiming to achieve optimal physiological adaptations. However, the repetitive nature of such damage increases the risk of injury. The ability to assess an athlete's susceptibility to fragility is therefore crucial for optimizing their training and performance. Genetic factors appear to play a significant role in the occurrence of these injuries, particularly through subtle variations in DNA sequences. Depending on the location of these variations within a gene, they may or may not alter the expression or function of the associated protein. The investigators aimed to investigate the relationship between genetic polymorphisms and biological parameters in the context of exercise-induced muscle damage.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female
  • Aged between 18 and 35
  • Weighing more than 50 kg
  • Member of a sports club affiliated to an Olympic federation
  • Socially insured
  • Willing to comply with all study procedures and duration of the study

Exclusion criteria

  • Medical history contraindicating sporting activities
  • Current medical treatment
  • Not a member of a sports club affiliated to an Olympic federation
  • Administrative reasons: impossibility of receiving informed information, impossibility of participating in the entire study, absence of social security coverage, refusal to sign consent form.

Treatment and study plan

Exercise

Other

Muscle induced-damage eccentric exercise

Primary outcomes

  1. The association between single nucleotide polymorphisms and exercise induced blood creatine kinase variation

    Time frame: Evolution of kinetics from Day 0 to Day 3 post experiment

    Association between blood creatine kinase level variations and single nucleotide polymorphisms.

    The Outcome Measure in this study is focused on the variation in plasma CPK levels following an exercise inducing muscle damage. The result is expressed as a change in plasma CPK concentration, measured in units per liter (U/L). This single measurement is used to investigate its association with genetic polymorphisms. Therefore a regression analysis will be performed to identify the association. This study is exploratory and the genetic polymorphisms are not pre-identified but will be investigated through a comprehensive analysis.

Sponsors and collaborators

Lead sponsor

Lille University

Other

Registry information

Official study title

Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS) / Déterminants Génétiques Des Dommages Musculaires Induits Par L'exercice (POLYGENDOMUS)

Acronym: POLYGENDOMUS

Important dates

Study start
2023
Primary completion
2024
Study completion
2025
First posted
Dec 18, 2024
Registry last updated
Dec 18, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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